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. 1988 Feb;8(2):709-14.
doi: 10.1523/JNEUROSCI.08-02-00709.1988.

Interleukin-1 is an astroglial growth factor in the developing brain

D Giulian  1 , D G Young, J Woodward, D C Brown, L B Lachman
Affiliations

Interleukin-1 is an astroglial growth factor in the developing brain

D Giulian et al. J Neurosci. 1988 Feb.

Abstract

The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In vitro studies indicate that ameboid microglia, a class of brain mononuclear phagocytes, are the likely source of IL-1. Examination of different brain regions during development shows IL-1 production only after the appearance of ameboid microglia. These observations suggest that brain mononuclear phagocytes secrete growth factors that regulate normal growth and development of the CNS.

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