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Review
. 2020 Jun 19;12(6):662.
doi: 10.3390/v12060662.

The Interplay between Adeno-Associated Virus and its Helper Viruses

Anita F Meier  1 , Cornel Fraefel  1 , Michael Seyffert  1
Affiliations
Review

The Interplay between Adeno-Associated Virus and its Helper Viruses

Anita F Meier et al. Viruses. .

Abstract

The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.

Keywords: adeno-associated virus; adenovirus; helper virus; herpes simplex virus; viral coinfections; viral vectors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Boxed texts on the left (green) describe each step during AAV replication. The role of HSV-1 (yellow) or AdV5 (red) helper factors and interfering cellular factors (purple) are indicated in the figure and described on the right. AAV Rep-proteins are depicted in green. HSV-1 and AdV5 helper factors in Step 6 are unclear and, therefore, put in brackets.
See this image and copyright information in PMC

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