doi: 10.1126/science.3257586.
One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes
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- PMID: 3257586
- DOI: 10.1126/science.3257586
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One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes
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Abstract
Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes alpha 1-antitrypsin and transthyretin appear to bind the same nuclear protein that is found mainly in the liver. Such proteins may provide a basis for a coordinated, hepatocyte-specific control of gene transcription.
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