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. 1988 Feb 12;239(4841 Pt 1):786-8.
doi: 10.1126/science.3257586.

One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes

D R Grayson  1 , R H Costa, K G Xanthopoulos, J E Darnell
Affiliations

One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes

D R Grayson et al. Science. .

Abstract

Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes alpha 1-antitrypsin and transthyretin appear to bind the same nuclear protein that is found mainly in the liver. Such proteins may provide a basis for a coordinated, hepatocyte-specific control of gene transcription.

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