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. 2020 Jul;21(7):710-712.
doi: 10.1038/s41590-020-0671-z.

The immunology of blood: connecting the dots at the neurovascular interface

Katerina Akassoglou  1
Affiliations

The immunology of blood: connecting the dots at the neurovascular interface

Katerina Akassoglou. Nat Immunol. 2020 Jul.

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Figures

Photo:
Photo:
Katerina Akassoglou, PhD in her laboratory at Gladstone Institutes, University of California San Francisco in 2019.
Figure 1
Figure 1
Fibrin mechanisms and functions in neuroinflammation. Upon BBB disruption, fibrinogen leaks in the brain and by activation of the coagulation cascade it is converted to insoluble fibrin deposits. Fibrin activates microglia and promotes recruitment of peripheral immune cells and oxidative injury leading to tissue damage. Inhibition of the interaction of fibrin with its cellular receptors could enable the discovery of selective therapies to block the toxic effects of blood leaks in a wide range of diseases with vascular damage and inflammation.
See this image and copyright information in PMC

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