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Comparative Study
. 2019;39(2):20-26.

The Effect of Pulsed Electromagnetic Field and Combined Magnetic Field Exposure Time on Healing of a Rabbit Tibial Osteotomy

Douglas C Fredericks  1 , Emily B Petersen  1 , Madison Rhodes  1 , Grace A Larew  1 , James V Nepola  1
Affiliations
Comparative Study

The Effect of Pulsed Electromagnetic Field and Combined Magnetic Field Exposure Time on Healing of a Rabbit Tibial Osteotomy

Douglas C Fredericks et al. Iowa Orthop J. 2019.

Abstract

Background: This study compares effectiveness of two commercially available signals, Pulsed Electromagnetic Field (PEMF) and Combined Magnetic Field (CMF) clinical signals, to stimulate bone healing in rabbit tibial osteotomies.

Methods: One millimeter osteotomies in New Zealand White rabbits, stabilized with external fixators, were exposed daily to either signal for 30 minutes, three or six hours. Osteotomized sham controls received no signal exposure. Analyses of torsional strength, periosteal callus area and fracture healing stage demonstrated dose responses to increasing daily exposures to both signals.

Results: By 14 days torsional strength increased over shams in the three and six hour-treated groups, significant only for the six hour groups (p<0.05). By 21 days both three and six hour-treated groups were significantly stronger than shams (p<0.05, p<0.005) and the PEMF 30 minute treated group also showed significance (p<0.05). PEMF versus CMF-treated groups were not different at any exposure time.

Conclusions: Both CMF and PEMF signals were most effective in this model when used for six hours per day.

Clinical relevance: In this model we demonstrate that though both PEMF and CMF are "bioactive" and promote healing at shorter and longer exposure dosages, there exists an "optimal" threshold effect of 6 hours/day electromagnetic wave stimulation for bone healing.

Keywords: Combined Magnetic Field; Pulsed Electromagnetic Field; animal model; fracture healing.

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Conflict of interest statement

Disclosures: The authors report no potential conflicts of interest related to this study.

Figures

Figure 1
Figure 1
Biomechanical testing of osteotomy healing showing torsional strength values as a function of treatment with PEMF or CMF signals at three different daily exposure times after 14 days (a) and 21 days (b) post-osteotomy.
Figure 2
Figure 2
Biomechanical testing of osteotomy healing showing stiffness as a function of treatment with PEMF or CMF signals at three different daily exposure times after 14 days (a) and 21 days (b) post-osteotomy.
Figure 3
Figure 3
Radiographic analysis of the relative area of periosteal callus to diaphyseal bone as a function of daily exposure time to the PEMF or CMF signal 14 days (a) and 21 days (b) post-osteotomy.
See this image and copyright information in PMC

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