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Case Reports
. 2020 Jun 19:16:51.
doi: 10.1186/s13223-020-00452-y. eCollection 2020.

Anaphylaxis to clindamycin following cutaneous exposure

N Paradis  1 , L Marois  1 , L Paradis  1   2 , F Graham  1   2 , P Bégin  1   2   3 , A Des Roches  1   3
Affiliations
Case Reports

Anaphylaxis to clindamycin following cutaneous exposure

N Paradis et al. Allergy Asthma Clin Immunol. .

Abstract

Background: The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.

Case presentation: We describe the first case of intravenous clindamycin anaphylaxis, with likely sensitization due to previous topical exposure to clindamycin gel for acne in a 14-year-old boy with history of atopy and mild atopic dermatitis.

Conclusion: This case highlights the potential sensitization to drug allergens, including antibiotics, via the skin.

Keywords: Antibiotic anaphylaxis; Atopic dermatitis; Transcutaneous exposition.

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Conflict of interest statement

Competing interestsI declare that I haven’t competing interests.

References

    1. Dreno B. Topical antibacterial therapy for acne vulgaris. Drugs. 2004;64(21):2389–2397. doi: 10.2165/00003495-200464210-00002. - DOI - PubMed
    1. Czarnowicki T, Krueger JG, Guttman-Yassky E. Skin barrier and immune dysregulation in atopic dermatitis: an evolving story with important clinical implications. J Allergy Clin Immunol Pract. 2014;2:371–379. doi: 10.1016/j.jaip.2014.03.006. - DOI - PubMed
    1. Boguniewicz M, Leung DY. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immuno Rev. 2011;242(1):233–246. doi: 10.1111/j.1600-065X.2011.01027.x. - DOI - PMC - PubMed
    1. Brough HA, Liu AH, Sicherer S, Makinson K, Douiri A, Brown SH, et al. Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy. J Allergy Clin. 2015;135(1):164–170. doi: 10.1016/j.jaci.2014.10.007. - DOI - PMC - PubMed
    1. Saleh MM, Forkel S, Schön MP, Fuchs T, Buhl T. Profile shift in latex sensitization over the last 20 years. Int Arch Allergy Immunol. 2019;178:83–88. doi: 10.1159/000492191. - DOI - PubMed

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