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Case Reports
. 2020 Apr 8;8(6):933-937.
doi: 10.1002/ccr3.2706. eCollection 2020 Jun.

Management of central nervous system relapse in a young patient affected by primary mediastinal large B-cell lymphoma: A case report

Miriam Marangon  1 , Beatrice Casadei  1 , Alessandro Broccoli  1 , Lisa Argnani  1 , Michele Cavo  1 , Pier Luigi Zinzani  1
Affiliations
Case Reports

Management of central nervous system relapse in a young patient affected by primary mediastinal large B-cell lymphoma: A case report

Miriam Marangon et al. Clin Case Rep. .

Abstract

In primary mediastinal large B-cell lymphoma, central nervous system (CNS) relapse is an uncommon event with a dismal prognosis. We report about the successful management of CNS relapse with chemoimmunotherapy according to MATRix (methotrexate, cytarabine, thiotepa, and rituximab) protocol followed by autologous stem cell transplant.

Keywords: MATRix regimen; autologous stem cell transplant; central nervous system involvement; primary mediastinal large B‐cell lymphoma.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Magnetic resonance imaging at central nervous system lymphoma recurrence
Figure 2
Figure 2
Magnetic resonance imaging at the end of MATRix (methotrexate, cytarabine, thiotepa, and rituximab) regimen (complete response)
See this image and copyright information in PMC

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