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Comment
. 2021 Feb;288(3):799-802.
doi: 10.1111/febs.15437. Epub 2020 Jun 23.

Immunomodulation via macrophages to fight solid tumor malignancies

Hiren Dandia  1 , Prakriti Tayalia  1
Affiliations
Free article
Comment

Immunomodulation via macrophages to fight solid tumor malignancies

Hiren Dandia et al. FEBS J. 2021 Feb.
Free article

Abstract

The paper 'A C-Terminal Fragment of Adhesion Protein Fibulin-7 Inhibits Growth of Murine Breast Tumor by Regulating Macrophage Reprogramming' by Chakraborty et al. highlights that Fbln7-C could be explored as a potential immunomodulatory agent against various solid cancers and have shown its abilities to regulate tumor microenvironment reprogramming of TAMs in a breast cancer model. Fbln7, which is a secreted glycoprotein, has been shown to be anti-angiogenic and has an immunomodulatory role regulating various functional properties of monocytes, macrophages, and neutrophils, thereby influencing inflammation. In this study, the authors have shown that in a murine breast tumor model, intravenous administration of Fbln7-C significantly reduces the size of tumors via macrophage reprogramming. Comment on: https://doi.org/10.1111/febs.15333.

Keywords: fibulins; immunomodulation; macrophages; solid tumor.

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References

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