Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis)

doi:10.1093/cid/ciaa348

. 2020 Jun 24;71(Suppl 1):S1-S3.

doi: 10.1093/cid/ciaa348.

Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis)

Ellen N Kersh¹, Kimberly A Workowski^{1

2}

Affiliations

¹ Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Department of Medicine, Division of Infectious Diseases, Emory University, Atlanta, Georgia, USA.

PMID: 32578867
PMCID: PMC7315932
DOI: 10.1093/cid/ciaa348

Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis)

Ellen N Kersh et al. Clin Infect Dis. 2020.

. 2020 Jun 24;71(Suppl 1):S1-S3.

doi: 10.1093/cid/ciaa348.

Authors

Ellen N Kersh¹, Kimberly A Workowski^{1

2}

Affiliations

¹ Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Department of Medicine, Division of Infectious Diseases, Emory University, Atlanta, Georgia, USA.

PMID: 32578867
PMCID: PMC7315932
DOI: 10.1093/cid/ciaa348

Abstract

The articles in this supplement address key questions on syphilis diagnostics, provide reference tables of test performances, and discuss optimal specimens and knowledge gaps. Laboratory-developed genetic direct detection tests could be most useful at the point of care and add to the currently available serologic methods of nontreponemal and treponemal tests.

Keywords: Treponema pallidum direct detection; serology; syphilis diagnostics; systematic review.

Published by Oxford University Press for the Infectious Diseases Society of America 2020.

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References

1. Centers for Disease Control and Prevention. Syphilis strikes back.2017. Available at: https://www.cdc.gov/std/sam/2017syphilis.htm. Accessed 8 August 2018.
1. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance 2018. Available at: https://www.cdc.gov/std/stats18/default.htm. Accessed 11 July 2019.
1. Kersh EN, Lukehart SA. Biomedical research priorities for modern syphilis clinical management, diagnosis, and vaccines: overview and commentary for unit 1. Sex Transm Dis 2018; 45:7–9. - PMC - PubMed
1. Centers for Disease Control and Prevention. Syphilis testing algorithms using treponemal tests for initial screening—four laboratories, New York City, 2005–2006. MMWR Morb Mortal Wkly Rep 2008; 57:872–5. - PubMed
1. Centers for Disease Control and Prevention. Discordant results from reverse sequence syphilis screening—five laboratories, United States, 2006–2010. MMWR Morb Mortal Wkly Rep 2011; 60:133–7. - PubMed

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[1] Centers for Disease Control and Prevention. Syphilis strikes back.2017. Available at: https://www.cdc.gov/std/sam/2017syphilis.htm. Accessed 8 August 2018.

[2] Centers for Disease Control and Prevention. Syphilis strikes back.2017. Available at: https://www.cdc.gov/std/sam/2017syphilis.htm. Accessed 8 August 2018.

[3] Centers for Disease Control and Prevention. Sexually transmitted disease surveillance 2018. Available at: https://www.cdc.gov/std/stats18/default.htm. Accessed 11 July 2019.

[4] Centers for Disease Control and Prevention. Sexually transmitted disease surveillance 2018. Available at: https://www.cdc.gov/std/stats18/default.htm. Accessed 11 July 2019.

[5] Kersh EN, Lukehart SA. Biomedical research priorities for modern syphilis clinical management, diagnosis, and vaccines: overview and commentary for unit 1. Sex Transm Dis 2018; 45:7–9. - PMC - PubMed

[6] Kersh EN, Lukehart SA. Biomedical research priorities for modern syphilis clinical management, diagnosis, and vaccines: overview and commentary for unit 1. Sex Transm Dis 2018; 45:7–9. - PMC - PubMed

[7] Centers for Disease Control and Prevention. Syphilis testing algorithms using treponemal tests for initial screening—four laboratories, New York City, 2005–2006. MMWR Morb Mortal Wkly Rep 2008; 57:872–5. - PubMed

[8] Centers for Disease Control and Prevention. Syphilis testing algorithms using treponemal tests for initial screening—four laboratories, New York City, 2005–2006. MMWR Morb Mortal Wkly Rep 2008; 57:872–5. - PubMed

[9] Centers for Disease Control and Prevention. Discordant results from reverse sequence syphilis screening—five laboratories, United States, 2006–2010. MMWR Morb Mortal Wkly Rep 2011; 60:133–7. - PubMed

[10] Centers for Disease Control and Prevention. Discordant results from reverse sequence syphilis screening—five laboratories, United States, 2006–2010. MMWR Morb Mortal Wkly Rep 2011; 60:133–7. - PubMed

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Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis)

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Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis)

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