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Review
. 2020 Nov;40(6):2114-2131.
doi: 10.1002/med.21702. Epub 2020 Jun 24.

Emerging use of senolytics and senomorphics against aging and chronic diseases

Jan Martel  1   2 , David M Ojcius  1   2   3 , Cheng-Yeu Wu  1   2   4 , Hsin-Hsin Peng  1   2   5 , Laurent Voisin  6 , Jean-Luc Perfettini  3   6 , Yun-Fei Ko  2   7   8 , John D Young  1   2   7   8
Affiliations
Review

Emerging use of senolytics and senomorphics against aging and chronic diseases

Jan Martel et al. Med Res Rev. 2020 Nov.

Abstract

Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.

Keywords: aging; apoptosis; dietary supplements; phytochemicals; senescence.

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References

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