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Comment
. 2021 Jan;93(1):124-126.
doi: 10.1002/jmv.26217. Epub 2020 Jul 6.

Clinical and biological data on the use of hydroxychloroquine against SARS-CoV-2 could support the role of the NLRP3 inflammasome in the pathogenesis of respiratory disease

Alessandro Lucchesi  1 , Paolo Silimbani  2 , Gerardo Musuraca  1 , Claudio Cerchione  1 , Giovanni Martinelli  3 , Paola Di Carlo  4 , Mariasanta Napolitano  5
Affiliations
Comment

Clinical and biological data on the use of hydroxychloroquine against SARS-CoV-2 could support the role of the NLRP3 inflammasome in the pathogenesis of respiratory disease

Alessandro Lucchesi et al. J Med Virol. 2021 Jan.
No abstract available

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Activation of the NLRP3 inflammasome by a two‐step mechanism. First, pathogen‐associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs) interact with the toll‐like receptor (TLR) of alveolar macrophages leading to the induction of interleukin genes via nuclear factor kB (NF‐kB). Secondly, the mature and active forms of interleukin‐8 (IL‐18) and IL‐1β are obtained from the action of caspase‐1, part of the inflammasome protein scaffold
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References

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