doi: 10.1084/jem.167.2.315.
A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor
Affiliations
- PMID: 3258004
- PMCID: PMC2188863
- DOI: 10.1084/jem.167.2.315
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A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor
J Exp Med.
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Abstract
This report describes an avian TCR molecule, TCR1, whose molecular characteristics, signal-transducing property, and tissue distribution suggest that it is a homologue of the mammalian TCR-gamma/delta. TCR1+ cells are the first to be generated in the thymus during ontogeny, preceding other T3+ cells by approximately 3 d. Unlike their mammalian counterpart, TCR1+ cells constitute a relatively large subpopulation of peripheral T cells in mature chickens. These results suggest a phylogenetically important role for this receptor in T cell development and function.
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