Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 1;28(3):293-303.
doi: 10.5551/jat.56333. Epub 2020 Jun 24.

The Effect of Common Variants in SLC44A2 on the Contribution to the Risk of Deep Cein Thrombosis after Orthopedic Surgery

Liqiang Zhi  1 , Weilou Feng  2 , Jingqi Liang  3 , Qing Zhong  1 , Liaoyuan Ren  4 , Jianbing Ma  1 , Shuxin Yao  1 ; Liqiang Zhi, Weilou Feng and Jingqi Liang contributed equally to this work
Affiliations

The Effect of Common Variants in SLC44A2 on the Contribution to the Risk of Deep Cein Thrombosis after Orthopedic Surgery

Liqiang Zhi et al. J Atheroscler Thromb. .

Abstract

Aim: Deep vein thrombosis (DVT) is a common complication of orthopedic surgery. Multiple lines of evidence indicate that genetic factors play an important role in the development of DVT following orthopedic surgery (DVTFOS). Recent evidence suggested that the solute carrier family 44 member 2 (SLC44A) gene may contribute to the risk of DVT. In this study, we aimed to investigate the associations of SLC44A2 and DVTFOS in Chinese Han individuals.

Methods: In the study, 2,655 subjects, including 689 DVTFOS patients and 1,966 controls, were recruited. Eighteen SNPs were genotyped in the study. Genetic association analyses were performed at both the single marker and haplotype levels. Bioinformatics analyses were conducted to predict the functional consequences of significant SNPs.

Results: SNP rs2288904 of SLC44A2 was identified as being significantly associated with DVTFOS (P = 0.0003, OR [95%CI] = 1.28[1.12-1.46]). Allelic analyses showed that the G allele of this SNP significantly elevated the risks of DVTFOS, which was replicated in the genotypic association analyses. Moreover, a two-SNP haplotype, including rs2288904, was found to be strongly correlated with the risk of DVTFOS (P = 4.15×10－11). Widespread effects in the expression quantitative trait loci were identified for rs2288904 in multiple tissues.

Conclusion: In summary, our results provide further supportive evidence of the association of SLC44A2 with the risk of DVTFOS, which also provide clues for understanding the important roles of the SLC44A2 gene in the pathogenesis of DVTFOS and in the development of preventive strategies.

Keywords: Case–control study; Deep vein thrombosis; Genetic association; SLC44A2; Single nucleotide polymorphisms.

PubMed Disclaimer

Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Flow diagram of cases and control selection for the study design
Supplemental Fig. 1.
Supplemental Fig. 1.
Q-Q plot for results of single marker based association analyses
Fig. 2.
Fig. 2.
Regional association plot based on the results from the single marker-based association Analyses
Fig. 3.
Fig. 3.
Linkage disequilibrium structure of the 18 SNPs Values of D' are indicated in each cell.
Fig. 4.
Fig. 4.
Interaction network constructed based on protein-protein interaction data Blue and pink lines mean experimentally determined interactions.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Huang L, Li J and Jiang Y: Association between hypertension and deep vein thrombosis after orthopedic surgery: a meta-analysis. Eur J Med Res, 2016; 21: 13 - PMC - PubMed
    1. Neglen P, Thrasher TL and Raju S: Venous outflow obstruction: An underestimated contributor to chronic venous disease. J Vasc Surg, 2003; 38: 879-885 - PubMed
    1. Qin J, Dai J, Xu Z, Chen D, Qin J, Shi D, Teng H and Jiang Q: Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population. PLoS One, 2013; 8: e70033 - PMC - PubMed
    1. Souto JC, Almasy L, Borrell M, Blanco-Vaca F, Mateo J, Soria JM, Coll I, Felices R, Stone W, Fontcuberta J and Blangero J: Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study. Genetic Analysis of Idiopathic Thrombophilia. Am J Hum Genet, 2000; 67: 1452-1459 - PMC - PubMed
    1. Larsen TB, Sorensen HT, Skytthe A, Johnsen SP, Vaupel JW and Christensen K: Major genetic susceptibility for venous thromboembolism in men: a study of Danish twins. Epidemiology, 2003; 14: 328-332 - PubMed

MeSH terms

Substances