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Review
. 2020 May 27:16:483-492.
doi: 10.2147/TCRM.S197941. eCollection 2020.

Statin-Associated Autoimmune Myopathy: Current Perspectives

Eleni Tiniakou  1
Affiliations
Review

Statin-Associated Autoimmune Myopathy: Current Perspectives

Eleni Tiniakou. Ther Clin Risk Manag. .

Abstract

Although generally well tolerated, statin users frequently report muscle-related side effects, ranging from self-limiting myalgias to rhabdomyolysis or the rare clinical entity of statin-associated immune-mediated necrotizing myopathy (IMNM). Statin-associated IMNM is based on the development of autoantibodies against 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the pharmacologic target of statins, and leads to a necrotizing myopathy requiring immunosuppressive therapy. This review attempts to recapitulate the diverse aspects of anti-HMGCR IMNM, including clinical presentation, diagnostic modalities, genetic risk associations, therapeutic options and potential pathogenetic pathways.

Keywords: anti-HMGCR; myopathy; stains; statin myopathy; statin toxicity.

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Conflict of interest statement

The author reports no conflicts of interest in this work.

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