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. 2020 Jun 9:11:313.
doi: 10.3389/fpsyt.2020.00313. eCollection 2020.

Chronicity and Sex Affect Genetic Risk Prediction in Schizophrenia

Sandra M Meier  1 , Anna K Kähler  2 , Sarah E Bergen  2   3 , Patrick F Sullivan  2   4 , Christina M Hultman  2 , Manuel Mattheisen  5   6   7   8
Affiliations

Chronicity and Sex Affect Genetic Risk Prediction in Schizophrenia

Sandra M Meier et al. Front Psychiatry. .

Abstract

Schizophrenia (SCZ) is a severe mental disorder with immense personal and societal costs; identifying individuals at risk is therefore of utmost importance. Genomic risk profile scores (GRPS) have been shown to significantly predict cases-control status. Making use of a large-population based sample from Sweden, we replicate a previous finding demonstrating that the GRPS is strongly associated with admission frequency and chronicity of SCZ. Furthermore, we were able to show a substantial gap in prediction accuracy between males and females. In sum, our results indicate that prediction accuracy by GRPS depends on clinical and demographic characteristics.

Keywords: course; polygenic risk score; prediction; schizophrenia; sex.

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