Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Jun 3:11:516.
doi: 10.3389/fpsyt.2020.00516. eCollection 2020.

Affective Switch Associated With Oral, Low Dose Ketamine Treatment in a Patient With Treatment Resistant Bipolar I Depression. Case Report and Literature Review

Alina Wilkowska  1 , Łukasz Szałach  1 , Jakub Słupski  1 , Aleksandra Wielewicka  1 , Małgorzata Czarnota  1 , Maria Gałuszko-Węgielnik  1 , Mariusz S Wiglusz  1 , Wiesław J Cubała  1
Affiliations
Case Reports

Affective Switch Associated With Oral, Low Dose Ketamine Treatment in a Patient With Treatment Resistant Bipolar I Depression. Case Report and Literature Review

Alina Wilkowska et al. Front Psychiatry. .

Abstract

There is a growing evidence for the rapid and robust antidepressive effect of ketamine in unipolar and bipolar treatment resistant depression although evidence for the risk of affective switch is still limited. This case presents bipolar I disorder patient with treatment resistant depressive episode experiencing a switch to manic episode with mixed features shortly after receiving eight subanaesthetic doses of oral ketamine as an add-on treatment preceded by 2-day period of manic symptoms.

Keywords: affective switch; bipolar I depression; ketamine; oral and subanaesthetic; treatment resistance.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Treatment timeline.
See this image and copyright information in PMC

References

    1. Nock MK, Hwang I, Sampson N, Kessler RC, Angermeyer M, Beautrais A, et al. Cross-national analysis of the associations among mental disorders and suicidal behavior: findings from the WHO World Mental Health Surveys. PloS Med (2009) 6. 10.1371/journal.pmed.1000123 - DOI - PMC - PubMed
    1. Nordentoft M, Mortensen PB, Pedersen CB. Absolute risk of suicide after first hospital contact in mental disorder. Arch Gen Psychiatry (2011) 68:1058–64. 10.1001/archgenpsychiatry.2011.113 - DOI - PubMed
    1. Baldessarini RJ, Vázquez GH, Tondo L. Bipolar depression: a major unsolved challenge. Int J Bipolar Disord (2020) 6 8(1):1. 10.1186/s40345-019-0160-1 - DOI - PMC - PubMed
    1. Zarate CA, Jr., Brutsche NE, Ibrahim L, Franco-Chaves J, Diazgranados N, Cravchik A, et al. Replication of ketamine’s antidepressant efficacy in bipolar depression: A randomized controlled add-on trial. Biol Psychiatry (2012) 71:939–46. 10.1016/j.biopsych.2011.12.010 - DOI - PMC - PubMed
    1. DiazGranados N, Ibrahim LA, Brutsche NE, Ameli R, Henter ID, Luckenbaugh DA, et al. Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder. J Clin Psychiatry (2010) 71:1605–11. 10.4088/JCP.09m05327blu - DOI - PMC - PubMed

Publication types

LinkOut - more resources