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. 2020 Jun;8(2):111-119.
doi: 10.1007/s40136-020-00279-6.

Sinonasal Squamous Cell Carcinoma: Etiology, Pathogenesis, and the Role of Human Papilloma Virus

Katya Elgart  1 , Daniel L Faden  1   2
Affiliations

Sinonasal Squamous Cell Carcinoma: Etiology, Pathogenesis, and the Role of Human Papilloma Virus

Katya Elgart et al. Curr Otorhinolaryngol Rep. 2020 Jun.

Abstract

Purpose of review: Sinonasal squamous cell carcinoma (SNSCC) is a rare disease with considerable histologic diversity. Currently, there is a poor understanding of the etiology and pathogenesis of SNSCC. Here, we review recent literature to summarize what is known regarding (1) the etiology of SNSCC, (2) the role of Human Papilloma Virus (HPV) in SNSCC, and (2) the molecular underpinnings of SNSCC.

Recent findings: 1. High risk HPVappears to play a role in the pathogenesis of a subset of SNSCCs. SNSCCs with high risk HPV have improved survival compared with those without HPV and occur in patients who are younger, similar to HPV mediated oropharyngeal cancer. 2. A subset of inverted papillomas have transcriptionally active low-risk HPV and have a higher risk of transformation, while low risk HPV negative inverted papillomas frequently have EGFR mutations.

Summary: SNSCC is a diverse disease with likely multiple etiologies including carcinogen, irritant exposure, and HPV. While not definitively proven, evidence supports a role for high-risk HPV in a subset of SNSCC, and low-risk HPV in a subset of inverted papillomas which transform to SNSCC. In-depth molecular and genomic studies are needed in SNSCC to better understand the genomic underpinnings and oncogenic drivers.

Keywords: HPV; Sinonasal squamous cell carcinoma.

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Conflict of interest statement

Conflict of Interest Katya Elgart and Daniel L. Faden declare that they have no conflict of interest.

References

    1. Turner JH, Reh DD. Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck. 2012. 10.1002/hed.21830. - DOI - PubMed
    1. Jain S, Li Y, Kuan EC, Tajudeen BA, Batra PS, Batra S. Prognostic factors in paranasal sinus squamous cell carcinoma and adenocarcinoma: a SEER database analysis. J Neurol Surgery, Part B Skull Base. 2019;80:258–63. - PMC - PubMed
    1. Dutta R, Dubal PM, Svider PF, Liu JK, Baredes S, Eloy JA. Sinonasal malignancies: a population-based analysis of site-specific incidence and survival. Laryngoscope. 2015. 10.1002/lary.25465. - DOI - PubMed
    1. Sanghvi S, Khan MN, Patel NR, Yeldandi S, Baredes S, Eloy JA. Epidemiology of sinonasal squamous cell carcinoma: a comprehensive analysis of 4994 patients. Laryngoscope. 2014;124:76–83. - PubMed
    1. Danesh-Sani SA, Sarafraz A, Chamani M, Derakhshandeh H. Paranasal sinuses malignancies: A 12-year review of clinical characteristics. Med Oral Patol Oral Cir Bucal. 2016. 10.4317/medoral.21170. - DOI - PMC - PubMed

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