Obstructive Sleep Apnea and Hypertension: A Review of the Relationship and Pathogenic Association
- PMID: 32582500
- PMCID: PMC7306640
- DOI: 10.7759/cureus.8241
Obstructive Sleep Apnea and Hypertension: A Review of the Relationship and Pathogenic Association
Abstract
Obstructive sleep apnea (OSA) is defined as episodes of hypopnea or apnea, which leads to a partial or complete block of airways. Hypertension, on the other hand, is defined as an increase in systemic arterial blood pressure to a certain threshold. OSA and hypertension share many common factors in pathophysiology, such as gender, obesity, unhealthy lifestyle, impaired quality of sleep, renin-angiotensin system, and increased fluid distribution. In order to manage our patients effectively, we need to explore further the correlation between the two conditions.
Keywords: continuous positive airway pressure (cpap); essential hypertension; obesity; sleep apnea; sleep apnea and hypertension; snoring.
Copyright © 2020, Bangash et al.
Conflict of interest statement
The authors have declared that no competing interests exist.
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References
-
- The association of obstructive sleep apnea and hypertension. Patel AR, Patel AR, Singh S, Singh S, Khawaja I. http://www.ncbi.nlm.nih.gov/pubmed/31410341 Cureus. 2019;11:0. - PMC - PubMed
-
- Non drowsy obstructive sleep apnea as a potential cause of resistant hypertension,a case report. Mirrakhimov AE. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355001/ BMC Pulm Med. 2012;12:16. - PMC - PubMed
-
- The prevalence of sleep apnea in Iran: a systematic review and meta-analysis. Sarokhani M, Goli M, Salarvand S, Ghanei Gheshlagh R. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690329/ Tanaffos. 2019;18:1–10. - PMC - PubMed
-
- Review of and updates on hypertension in obstructive sleep apnea. Ahmad M, Makati D, Akbar S. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632858/ Int J Hypertens. 2017;2017:1848375. - PMC - PubMed
-
- Hypertension and sleep apnea. Floras JS. http://www.ncbi.nlm.nih.gov/pubmed/26112299. Can J Cardiol. 2015;31:889–897. - PubMed
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