Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;25(24):2001031.
doi: 10.2807/1560-7917.ES.2020.25.24.2001031.

Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020

Elena Percivalle  1 , Giuseppe Cambiè  2 , Irene Cassaniti  1   3 , Edoardo Vecchio Nepita  1   3 , Roberta Maserati  1 , Alessandro Ferrari  1   3 , Raffaella Di Martino  1   3 , Paola Isernia  4 , Francesco Mojoli  3   5 , Raffaele Bruno  3   6 , Marcello Tirani  7   8 , Danilo Cereda  8 , Carlo Nicora  9 , Massimo Lombardo  10 , Fausto Baldanti  1   3
Affiliations

Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020

Elena Percivalle et al. Euro Surveill. 2020 Jun.

Erratum in

  • Author's correction for Euro Surveill. 2020;25(24).
    Eurosurveillance editorial team. Eurosurveillance editorial team. Euro Surveill. 2022 Jan;27(3):220120c1. doi: 10.2807/1560-7917.ES.2022.27.3.220120c1. Euro Surveill. 2022. PMID: 35057897 Free PMC article. No abstract available.

Abstract

We evaluated SARS-CoV-2 RNA and neutralising antibodies in blood donors (BD) residing in the Lodi Red Zone, Italy. Of 390 BDs recruited after 20 February 2020 - when the first COVID-19 case in Lombardy was identified, 91 (23%) aged 19-70 years were antibody positive. Viral RNA was detected in an additional 17 (4.3%) BDs, yielding ca 28% (108/390) with evidence of virus exposure. Five stored samples collected as early as 12 February were seropositive.

Keywords: Lodi Red Zone; SARS-CoV-2 seroprevalence; epidemiology; microneutralization assay.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Distribution of blood donors in the 10 municipalities of the Lodi Red Zone, including those recruited for the study and those testing positive for SARS-CoV-2 neutralising antibodies, Lombardy, Italy, 18 March–6 April 2020 (n = 2,272 blood donors)
Figure 2
Figure 2
Distribution of NT-Abs titres in convalescent patients and blood donors, Italy, 2011–2020 (n = 129 individuals)
See this image and copyright information in PMC

Comment in

References

    1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. China Novel Coronavirus Investigating and Research Team A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33. 10.1056/NEJMoa2001017 - DOI - PMC - PubMed
    1. World Health Organization (WHO). Novel coronavirus – China. Geneva: WHO; 12 Jan 2020. [Accessed 19 Jan 2020]. Available from: https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/
    1. Livingston E, Bucher K. Coronavirus Disease 2019 (COVID-19) in Italy. JAMA. 2020;323(14):1335. 10.1001/jama.2020.4344 - DOI - PubMed
    1. Ye M, Fu D, Ren Y, Wang F, Wang D, Zhang F, et al. Treatment with convalescent plasma for COVID-19 patients in Wuhan, China. J Med Virol. 2020. 10.1002/jmv.25882 - DOI - PMC - PubMed
    1. Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, et al. Deployment of convalescent plasma for the prevention and treatment of COVID-19. J Clin Invest. 2020;130(6):2757-65. 10.1172/JCI138745 - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources