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. 2020 Oct;40(11):1408-1417.
doi: 10.1002/pd.5778. Epub 2020 Sep 17.

Kidney impairment in fetal growth restriction: three-dimensional evaluation of volume and vascularization

Janaína Campos Senra  1 , Carlos Tadashi Yoshizaki  1 , Giovana Farina Doro  1 , Rodrigo Ruano  2 , Maria Augusta Bento Cicaroni Gibelli  3 , Agatha Sacramento Rodrigues  4 , Vera Hermina Kalika Koch  5 , Vera Lúcia Jornada Krebs  3 , Marcelo Zugaib  1 , Rossana Pulcineli Vieira Francisco  1 , Lisandra Stein Bernardes  1
Affiliations

Kidney impairment in fetal growth restriction: three-dimensional evaluation of volume and vascularization

Janaína Campos Senra et al. Prenat Diagn. 2020 Oct.

Abstract

Objectives: Renal development is impaired in fetal growth restriction (FGR). Renal size can be considered a surrogate of renal function in childhood, and could be impaired in that condition. Our aim was to evaluate the ratio of total renal volume, measured by three-dimensional ultrasound, to estimated fetal weight (TRV/EFW) among fetuses with and without growth restriction. Furthermore, we correlated TRV/EFW with fetal Doppler velocimetry and renal vascularization indexes and evaluated the association of renal volume and vascular parameters with adverse neonatal events in growth-restricted fetuses.

Methods: In a retrospective cohort, TRV and renal vascularization of growth-restricted and normal fetuses were evaluated by three-dimensional ultrasonography and VOCAL technique. Independent samples t-tests and Mann-Whitney test were used for comparisons between groups. Logistic regression model was applied to evaluate the association between renal characteristics and adverse neonatal events.

Results: Seventy-one growth-restricted fetuses were compared to 194 controls. The TRV/EFW was lower in the growth-restricted group (P < .001). In our sample, this ratio did not correlate with Doppler velocimetry parameters, renal vascular indexes or any adverse neonatal events.

Conclusion: The TRV/EFW ratio is decreased in FGR. Further studies are needed to investigate the association of this ratio with long-term renal outcomes.

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References

REFERENCES

    1. Murphy VE, Smith R, Giles WB, Clifton VL. Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus. Endocr Rev. 2006;27(2):141-169.
    1. Froen JF, Gardosi JO, Thurmann A, Francis A, Stray-Pedersen B. Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet Gynecol Scand. 2004;83(9):801-807.
    1. Haram K, Svendsen E, Myking O. Growth restriction: etiology, maternal and neonatal outcome. A Review Current Women's Health Reviews. 2007;3(3):145-160.
    1. Yu VYH, Upadhyay A. Neonatal management of the growth-restricted infant. Seminars in Fetal and Neonatal Medicine. 2004;9(5):403-409.
    1. Sharma Deepak, Farahbakhsh Nazanin, Shastri Sweta, Sharma Pradeep. Intrauterine growth restriction - part 2. The Journal of Maternal-Fetal & Neonatal Medicine. 2016;29(24):4037-4048. https://doi.org/10.3109/14767058.2016.1154525.

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