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Comment
. 2020 Jun 25;135(26):2331-2333.
doi: 10.1182/blood.2020005679.

Mouse models usher in precision medicine

Defu Zeng  1
Affiliations
Comment

Mouse models usher in precision medicine

Defu Zeng. Blood. .

Abstract

In this issue of Blood, Matsuzawa-Ishimoto et al report an intestinal organoid-based platform that re-creates genetic susceptibility to T-cell–mediated tissue injury as observed in a mouse model of intestinal graft-versus-host disease (GVHD), providing a roadmap for precision medicine.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Organoid cultures as a bridge between mouse models and humans: ATG16L1 deficiency in both mouse and human intestinal epithelial cells augments the susceptibility toward necroptosis induced by alloreactive T cells or inflammatory cytokines.
See this image and copyright information in PMC

Comment on

  • An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.
    Matsuzawa-Ishimoto Y, Hine A, Shono Y, Rudensky E, Lazrak A, Yeung F, Neil JA, Yao X, Chen YH, Heaney T, Schuster SL, Zwack EE, Axelrad JE, Hudesman D, Tsai JJ, Nichols K, Dewan MZ, Cammer M, Beal A, Hoffman S, Geddes B, Bertin J, Liu C, Torres VJ, Loke P, van den Brink MRM, Cadwell K. Matsuzawa-Ishimoto Y, et al. Blood. 2020 Jun 25;135(26):2388-2401. doi: 10.1182/blood.2019004116. Blood. 2020. PMID: 32232483 Free PMC article.

References

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    1. Castilla-Llorente C, Martin PJ, McDonald GB, et al. . Prognostic factors and outcomes of severe gastrointestinal GVHD after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2014;49(7):966-971. - PMC - PubMed
    1. Yi T, Chen Y, Wang L, et al. . Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood. 2009;114(14):3101-3112. - PMC - PubMed
    1. Ni X, Song Q, Cassady K, et al. . PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells. J Clin Invest. 2017;127(5):1960-1977. - PMC - PubMed
    1. Tugues S, Amorim A, Spath S, et al. . Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells. Sci Transl Med. 2018;10(469):eaat8410. - PubMed