Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 Jul 7;41(26):2453-2455.
doi: 10.1093/eurheartj/ehaa444.

Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system

Francesca Bartoli-Leonard  1 , Louis Saddic  2 , Elena Aikawa  1   3   4
Affiliations
Editorial

Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system

Francesca Bartoli-Leonard et al. Eur Heart J. .
No abstract available

PubMed Disclaimer

Figures

Take home figure
Take home figure
The role of ALDH2 in cardiovascular pathologies. ALDH2 mutation or inhibition reduces MAX levels and the expression of miR-31-5p, reducing myocardin production, thus inhibiting the production of contractile smooth muscle proteins and ultimately leading to the increased incidence of AAD. Conversely, a reduction in ALDH2 has been demonstrated to increase mitochondrial injury, reactive aldehyde production, and the presence of ROS, the latter two increasing p53 expression, leading to cellular apoptosis and ultimately an increase in myocardial infarction and coronary artery disease. AAD, aortic aneurysm/dissections; ALDH2, aldehyde dehydrogenase 2; CAD, coronary artery disease; MI, myocardial infarction; ROS, reactive oxygen species; SM Genes, smooth muscle cells; SRF, serum response factor .
None
See this image and copyright information in PMC

Comment on

References

    1. Thompson RW. Detection and management of small aortic aneurysms. N Engl J Med 2002;346:1484–1486. - PubMed
    1. Isselbacher EM. Thoracic and abdominal aortic aneurysms. Circulation 2005;111:816–828. - PubMed
    1. Yang K, Ren J, Li X, Wang Z, Xue L, Cui S, Sang W, Xu T, Zhang J, Yu J, Liu Z, Shang H, Pang J, Huang X, Chen Y, Xu F. Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype. Eur Heart J 2020;41:2442–2452. - PubMed
    1. Sun L, Ferreira JC, Mochly-Rosen D. ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance. Sci Transl Med 2011;3:107ra111. - PMC - PubMed
    1. Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler K, Chukro J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochley-Rosen D, Wu JC. Characterisation of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci Transl Med 2014;6:255ra130–255ra154. - PMC - PubMed

Substances