Cognitive Dysfunction in Older Adults with Type 2 Diabetes: Links, Risks, and Clinical Implications
- PMID: 32586471
- DOI: 10.1016/j.cger.2020.04.002
Cognitive Dysfunction in Older Adults with Type 2 Diabetes: Links, Risks, and Clinical Implications
Abstract
The prevalence of comorbid diabetes and cognitive dysfunction increases as the population ages. Diabetes increases the risk of progression of cognitive dysfunction through a spectrum of cognitive decline to mild cognitive impairment then to dementia. Cognitive dysfunction, especially impairment in the executive domain, has a negative impact on patients' self-care tasks. With further progression of dementia and the development of behavioral problems, the challenge to carers and health care professionals looking after these patients is significant. Therefore, clinical trials are needed to explore the impact of novel hypoglycemic therapy on cognitive function as an important outcome in this population.
Keywords: Cognitive dysfunction; Diabetes mellitus; Management; Older people.
Copyright © 2020 Elsevier Inc. All rights reserved.
Conflict of interest statement
Disclosure The authors have nothing to disclose.
Similar articles
-
Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study.Diabetes Care. 2020 Nov;43(11):2691-2701. doi: 10.2337/dc20-0892. Epub 2020 Sep 23. Diabetes Care. 2020. PMID: 32967921
-
Conversion of mild cognitive impairment to dementia among subjects with diabetes: a population-based study of incidence and risk factors with five years of follow-up.J Alzheimers Dis. 2015;43(4):1441-9. doi: 10.3233/JAD-141566. J Alzheimers Dis. 2015. PMID: 25159674
-
Cognitive Dysfunction in Older Adults With Diabetes: What a Clinician Needs to Know.Diabetes Care. 2017 Apr;40(4):461-467. doi: 10.2337/dc16-1229. Diabetes Care. 2017. PMID: 28325796
-
Novel Treatment Opportunities Against Cognitive Impairment in Parkinson's Disease with an Emphasis on Diabetes-Related Pathways.CNS Drugs. 2019 Feb;33(2):143-160. doi: 10.1007/s40263-018-0601-x. CNS Drugs. 2019. PMID: 30687888 Free PMC article. Review.
-
[Diabetes mellitus and dementia].Vnitr Lek. 2012 Apr;58(4):305-8. Vnitr Lek. 2012. PMID: 22559805 Review. Czech.
Cited by
-
Risk factors for cognitive dysfunction and glycemic management in older adults with type 2 diabetes mellitus: a retrospective study.BMC Endocr Disord. 2023 Oct 11;23(1):220. doi: 10.1186/s12902-023-01476-2. BMC Endocr Disord. 2023. PMID: 37821909 Free PMC article.
-
Type 2 diabetes mellitus and cognitive decline in older adults in Germany - results from a population-based cohort.BMC Geriatr. 2022 May 26;22(1):455. doi: 10.1186/s12877-022-03151-y. BMC Geriatr. 2022. PMID: 35619073 Free PMC article.
-
The role of neurovascular coupling dysfunction in cognitive decline of diabetes patients.Front Neurosci. 2024 Mar 21;18:1375908. doi: 10.3389/fnins.2024.1375908. eCollection 2024. Front Neurosci. 2024. PMID: 38576869 Free PMC article. Review.
-
Expanding the Role of Continuous Glucose Monitoring in Modern Diabetes Care Beyond Type 1 Disease.Diabetes Ther. 2023 Aug;14(8):1241-1266. doi: 10.1007/s13300-023-01431-3. Epub 2023 Jun 16. Diabetes Ther. 2023. PMID: 37322319 Free PMC article. Review.
-
Plasma Nesfatin-1: Potential Predictor and Diagnostic Biomarker for Cognitive Dysfunction in T2DM Patient.Diabetes Metab Syndr Obes. 2021 Aug 10;14:3555-3566. doi: 10.2147/DMSO.S323009. eCollection 2021. Diabetes Metab Syndr Obes. 2021. PMID: 34408457 Free PMC article.
