Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Apr;85(8):2738-42.
doi: 10.1073/pnas.85.8.2738.

A tissue-specific DNase I-hypersensitive site in a class II A alpha gene is under trans-regulatory control

H C Liou  1 , B S Polla, D Aragnol, L D Leserman, I J Griffith, L H Glimcher
Affiliations

A tissue-specific DNase I-hypersensitive site in a class II A alpha gene is under trans-regulatory control

H C Liou et al. Proc Natl Acad Sci U S A. 1988 Apr.

Abstract

Class II major histocompatibility complex molecules are integral membrane glycoproteins whose distribution is limited to certain tissues. To identify the molecular basis for such specificity, the chromatin configuration of the class II A alpha gene was examined in intact nuclei from various cell types. We show that there are three DNase I-hypersensitive sites in the A alpha gene. One of these sites, located near the promoter region, is specific to cells that normally express class II molecules at some stage of differentiation. Furthermore, this tissue-specific site appears to be under trans-regulatory control.

PubMed Disclaimer

References

    1. J Immunol. 1979 Oct;123(4):1548-50 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Feb;84(4):1090-3 - PubMed
    1. Nature. 1982 May 27;297(5864):289-95 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Jan;81(1):95-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Apr;81(7):2045-9 - PubMed

Publication types

Substances

LinkOut - more resources