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. 2020 Jun;7(1):e000398.
doi: 10.1136/lupus-2020-000398.

Disease duration, age at diagnosis and organ damage are important factors for cardiovascular disease in SLE

Ola Nived  1 , Ragnar Freyr Ingvarsson  2   3 , Anna Jöud  4 , Petrus Linge  2 , Helena Tydén  2 , Andreas Jönsen  2 , Anders A Bengtsson  2
Affiliations

Disease duration, age at diagnosis and organ damage are important factors for cardiovascular disease in SLE

Ola Nived et al. Lupus Sci Med. 2020 Jun.

Erratum in

Abstract

Objective: To report the incidence rate ratios (IRR) of acute myocardial infarctions (AMI) and cerebrovascular events (CVE) in incident SLE cases from a defined population. To study the risk factors for cardiovascular events in all patients with SLE at our unit.

Methods: Patients with SLE diagnosed from 1981 to 2006 were followed through to 2016. IRRs of AMI and CVE were calculated. The AMI and CVE incidence patterns for patients with SLE were studied in relation to hypertension, smoking, renal dysfunction, anticardiolipin (aCL) antibodies at diagnosis, disease duration and organ damage before an event.

Results: 262 patients with SLE were included in the study; of these 175 were from the defined population. Overall, 37 AMI and 44 CVE were recorded. An increased IRR of 3 for AMI was found (p<0.001). Smoking, hypertension and reduced renal function were risk factors for AMI. An increased IRR of 3.3 for ischaemic CVE was found for women (p<0.001). Hypertension and aCL were risk factors for CVE. Organ damage before events was increased.

Conclusions: Cardiovascular events are increased in SLE and are associated with hypertension, smoking and increased damage rate.

Keywords: cardiovascular diseases; epidemiology; lupus erythematosus, systemic.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
SLE disease duration related to incidence rates for first myocardial infarction in the total SLE cohort and based on patients with an SLE diagnosis between 1981 and 2006 and followed through to 2016 (n=262 patients). IR, incidence rate.
Figure 2
Figure 2
SLE disease duration related to incidence rates for first cerebrovascular event in the total SLE cohort and based on patients with an SLE diagnosis between 1981 and 2006 and followed through to 2016 (n=262 patients). IR, incidence rate.
See this image and copyright information in PMC

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