Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Jun 25;7(5):e823.
doi: 10.1212/NXI.0000000000000823. Print 2020 Sep.

COVID-19-associated ophthalmoparesis and hypothalamic involvement

Elba Pascual-Goñi  1 , Juan Fortea  1 , Alejandro Martínez-Domeño  1 , Nuria Rabella  1 , Mario Tecame  1 , Cristina Gómez-Oliva  1 , Luis Querol  2 , Beatriz Gómez-Ansón  1
Affiliations
Case Reports

COVID-19-associated ophthalmoparesis and hypothalamic involvement

Elba Pascual-Goñi et al. Neurol Neuroimmunol Neuroinflamm. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. MRI findings in case 1 (A–D) and case 2 (E–H)
Case 1: (A) Sagittal fluid-attenuated inversion recovery (FLAIR) demonstrates an enlarged, hyperintense pituitary gland, thickened pituitary stalk, and hyperintense hypothalamus. T2/FLAIR-hyperintensity (HI) is also seen in the dorsal midbrain and pons. (B) Sagittal postcontrast 3D magnetization-prepared rapid gradient echo imaging T1 shows a heterogeneously enhancing pituitary and upper stalk. (C) Axial FLAIR shows HI in the tegmentum, involving the right abducens nucleus. (D) Coronal FLAIR shows a hyperintense pituitary gland, prominent HI in the periventricular region of the III ventricle, and subtle HI in the medial temporal lobes. Case 2: (E) Sagittal FLAIR demonstrates extensive HI in the hypothalamus and dorsal brainstem. (F) Axial FLAIR image shows HI and swelling of the hypothalamus, mammillary bodies, and dorsal midbrain. (G) Axial FLAIR demonstrates HI in the tectum of the midbrain and subtle HI in the medial temporal lobes. (H) Coronal FLAIR shows a prominent HI in the periventricular region of the III ventricle and in the mammillary bodies, and subtle HI in the medial temporal lobes.
See this image and copyright information in PMC

References

    1. Mao L, Wang M, Chen S, et al. . Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. SSRN Electron J Epub 2020 Feb 25.
    1. Zuccoli G, Cruz DS, Bertolini M, et al. . MR imaging findings in 56 patients with wernicke encephalopathy: nonalcoholics may differ from alcoholics. Am J Neuroradiol 2009;30:171–176. - PMC - PubMed
    1. Gutiérrez-Ortiz C, Méndez A, Rodrigo-Rey S, et al. . Miller Fisher Syndrome and polyneuritis cranialis in COVID-19. Neurology Epub 2020 Apr 27. 10.1212/WNL.0000000000009619. - DOI - PubMed
    1. Dinkin M, Gao V, Mbbs JK, et al. . COVID-19 presenting with ophthalmoparesis from cranial nerve palsy. Neurology Epub 2020 May 1. 10.1212/WNL.0000000000009700. - DOI - PubMed
    1. Poyiadji N, Shahin G, Noujaim D, Stone M, Pate P, Griffith B. COVID-19–associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features. Radiology 2019;2:1–19. - PMC - PubMed

Publication types