Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 Jun;12(6):325-328.
doi: 10.14740/jocmr4225. Epub 2020 Jun 4.

Opportunities and Limitations in the Study of Transient Takotsubo Syndrome in Animal Models

Paolo Angelini  1 , Maria T Gamero  2
Affiliations
Editorial

Opportunities and Limitations in the Study of Transient Takotsubo Syndrome in Animal Models

Paolo Angelini et al. J Clin Med Res. 2020 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

None to declare.

Figures

Figure 1
Figure 1
Diagrammatic representation of the dynamic factors involved in the appearance and disappearance of TTS features. The red line represents the variable state of endothelial dysfunction (ED); an episode starts with borderline ED that worsens in response to some precipitating factor, and then recovers gradually over 1 - 2 days. The blue line indicates the appearance of severe epicardial coronary arterial spasm, which quickly resolves, while left ventricular dysfunction appears. Spastic transient occlusion must resolve in 15 - 60 min if no thrombosis occurs (which is rare). The blue area represents the time course of positive Ach testing (days 2 - 5). Usually, ED recovers to within normal limits on about day 5 (i.e., at the time of negative Ach testing) [20]. TTS: transient takotsubo syndrome.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Dote K, Sato H, Tateishi H, Uchida T, Ishihara M. [Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases] J Cardiol. 1991;21(2):203–214. - PubMed
    1. Ali A, Redfors B, Lundgren J, Alkhoury J, Oras J, Gan LM, Omerovic E. Effects of pretreatment with cardiostimulants and beta-blockers on isoprenaline-induced takotsubo-like cardiac dysfunction in rats. Int J Cardiol. 2019;281:99–104. doi: 10.1016/j.ijcard.2018.12.045. - DOI - PubMed
    1. Redfors B, Ali A, Shao Y, Lundgren J, Gan LM, Omerovic E. Different catecholamines induce different patterns of takotsubo-like cardiac dysfunction in an apparently afterload dependent manner. Int J Cardiol. 2014;174(2):330–336. doi: 10.1016/j.ijcard.2014.04.103. - DOI - PubMed
    1. Sachdeva J, Dai W, Kloner RA. Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy. J Am Heart Assoc. 2014;3(3):e000921. doi: 10.1161/JAHA.114.000921. - DOI - PMC - PubMed
    1. Shao Y, Redfors B, Scharin Tang M, Mollmann H, Troidl C, Szardien S, Hamm C. et al. Novel rat model reveals important roles of beta-adrenoreceptors in stress-induced cardiomyopathy. Int J Cardiol. 2013;168(3):1943–1950. doi: 10.1016/j.ijcard.2012.12.092. - DOI - PubMed

Publication types

LinkOut - more resources