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Review
. 2020 Sep;37(5):877-880.
doi: 10.1111/pde.14240. Epub 2020 Jun 26.

Use of topical rapamycin in acral pseudolymphomatous angiokeratoma of children (APACHE): A report of two cases and review of the literature

Seiwon Park  1 , Irene Lara-Corrales  2   3 , Elena Pope  2   3
Affiliations
Review

Use of topical rapamycin in acral pseudolymphomatous angiokeratoma of children (APACHE): A report of two cases and review of the literature

Seiwon Park et al. Pediatr Dermatol. 2020 Sep.

Abstract

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare, benign disease characterized clinically by multiple, asymptomatic, erythematous papules in the acral regions. We report APACHE in a 12-year-old girl with erythematous-violaceous papules on the lateral dorsum of her foot and toes, and a 3-year-old girl with erythematous papules on the plantar aspect of her foot. Topical rapamycin ointment improved the lesions and both patients tolerated the medication well. Topical rapamycin appears to be a potentially efficacious, well-tolerated, non-invasive therapy in APACHE, although further studies are needed.

Keywords: acral pseudolymphomatous angiokeratoma of children; angiokeratoma; rapamycin; sirolimus.

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References

REFERENCES

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