High-dose but Not Low-dose Corticosteroids Potentially Delay Viral Shedding of Patients With COVID-19

Sijia Li^{1

2}, Zhigang Hu^{1

2}, Xinyu Song^{1

2}

Affiliations

¹ Department of Respiratory and Critical Care Medicine, First College of Clinical Medicine Science, China Three Gorges University, Yichang, People's Republic of China.
² Department of Respiratory and Critical Care Medicine, Yichang Central People's Hospital, Yichang, People's Republic of China.

Sijia Li et al. Clin Infect Dis. 2021.

. 2021 Apr 8;72(7):1297-1298.

doi: 10.1093/cid/ciaa829.

Sijia Li^{1

2}, Zhigang Hu^{1

2}, Xinyu Song^{1

2}

¹ Department of Respiratory and Critical Care Medicine, First College of Clinical Medicine Science, China Three Gorges University, Yichang, People's Republic of China.
² Department of Respiratory and Critical Care Medicine, Yichang Central People's Hospital, Yichang, People's Republic of China.

No abstract available

References

1. National Health Commission of the People’s Republic of China. The notice of launching guideline on diagnosis and treatment of the novel coronavirus pneumonia (NCP) 5th edition revised [in Chinese]. Available at: http://www.nhc.gov.cn/xcs/zhengcwj/202002/d4b895337e19445f8d728fcaf1e3e1.... Accessed 8 February 8 2020.
1. Xu K, Chen Y, Yuan J, et al. . Factors associated with prolonged viral RNA shedding in patients with COVID-19 [manuscript published online ahead of print 9 April 2020]. Clin Infect Dis 2020. doi:10.1093/cid/ciaa351. - DOI - PMC - PubMed
1. Yang Z, Liu J, Zhou Y, et al. . The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis. J Infect 2020; 81:e13–20. - PMC - PubMed
1. Lee N, Allen Chan KC, Hui DS, et al. . Effects of early corticosteroid treatment on plasma SARS-associated coronavirus RNA concentrations in adult patients. J Clin Virol 2004; 31:304–9. - PMC - PubMed
1. Arabi YM, Mandourah Y, Al-Hameed F, et al. ; Saudi Critical Care Trial Group Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome. Am J Respir Crit Care Med 2018; 197:757–67. - PubMed