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. 1988 May 1;140(9):3040-4.

Stimulation of murine hemopoietic colony formation by human IL-6

G G Wong  1 , J S Witek-Giannotti, P A Temple, R Kriz, C Ferenz, R M Hewick, S C Clark, K Ikebuchi, M Ogawa
Affiliations
  • PMID: 3258892

Stimulation of murine hemopoietic colony formation by human IL-6

G G Wong et al. J Immunol. .

Abstract

A novel hemopoietic CSF has been identified in the medium conditioned by lectin-stimulated human T cells. The cDNA clone encoding this factor, isolated by functional expression cloning in monkey cos-1 cells, proved to be identical with the cDNA encoding the cytokine B cell stimulatory factor-2/IFN-beta 2, a factor now known as IL-6. In the murine system, IL-6 indirectly supports the formation of several different types of hemopoietic colonies, including those derived from early blast cells, and directly supports the proliferation of granulocyte/macrophage progenitors. These results expand the range of known target cells of IL-6 to include hemopoietic progenitors in addition to B cells, T cells, and fibroblasts and provide further evidence that this cytokine plays an important role within a network of interacting cytokines that regulates many different biologic responses.

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