Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Jan;37(1):e3376.
doi: 10.1002/dmrr.3376. Epub 2020 Jul 18.

Serum amyloid A protein has been undervalued as a biomarker of COVID-19

Carlos-Alberto Gonçalves  1 , Patrícia Sesterheim  2
Affiliations
Comment

Serum amyloid A protein has been undervalued as a biomarker of COVID-19

Carlos-Alberto Gonçalves et al. Diabetes Metab Res Rev. 2021 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Serum amyloid A (SAA) may play a key role in the pathogenesis of COVID‐19 in diabetic patients. Interleukin‐6 (IL‐6) induces the synthesis and release of acute‐phase proteins (APP) in hepatocytes. Serum amyloid A (SAA), which is already elevated in chronic inflammatory conditions (eg, obesity and diabetes mellitus), is one of the APP generated. This APP reinforces primary cytokine production, contributing to a cytokine storm. SAA directly binds to fibrinogen leading to an atypical coagulopathy. Moreover, it binds to apoB‐containing lipoproteins, leading to HDL dysfunction, and induces red blood cell (RBC) agglutination. Taken together, these changes contribute to embolic and multiinfarct events in COVID‐19
See this image and copyright information in PMC

Comment on

References

    1. Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C, Qin R, Wang H, Shen Y, Du K, Zhao L, Fan H, Luo S, Hu D. Diabetes is a risk factor for the progression and prognosis of COVID‐19. Diabetes/Metabolism Research and Reviews. 2020;e3319. 10.1002/dmrr.3319. - DOI - PMC - PubMed
    1. Hussain A, Bhowmik B. Do Vale Moreira NC. COVID‐19 and diabetes: knowledge in progress. Diabetes Res Clin Pract. 2020;162:108142. - PMC - PubMed
    1. Moore BJB, June CH. Cytokine release syndrome in severe COVID‐19. Science. 2020;368:473‐474. - PubMed
    1. Henderson LA, Canna SW, Schulert GS, et al. On the alert for cytokine storm: immunopathology in COVID‐19. Arthritis Rheumatol. 2020;72:1059‐1063. 10.1002/art.41285. - DOI - PMC - PubMed
    1. Fernandes BS, Steiner J, Molendijk ML, et al. C‐reactive protein concentrations across the mood spectrum in bipolar disorder: a systemic review and meta‐analysis. Lancet Psychiat. 2016;3:1147‐1156. - PubMed

Publication types