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Randomized Controlled Trial
. 2020 Jun 26;12(13):13740-13761.
doi: 10.18632/aging.103571. Epub 2020 Jun 26.

Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial

Amir Hadanny  1   2   3 , Malka Daniel-Kotovsky  1 , Gil Suzin  1 , Rahav Boussi-Gross  1 , Merav Catalogna  1 , Kobi Dagan  1 , Yafit Hachmo  4 , Ramzia Abu Hamed  1 , Efrat Sasson  1 , Gregory Fishlev  1 , Erez Lang  1 , Nir Polak  1 , Keren Doenyas  1 , Mony Friedman  1 , Sigal Tal  5 , Yonatan Zemel  1 , Yair Bechor  1 , Shai Efrati  1   2   4   6
Affiliations
Randomized Controlled Trial

Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial

Amir Hadanny et al. Aging (Albany NY). .

Abstract

More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study's aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults.A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging.There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788).Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7).In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging.

Keywords: aging; cerebral blood flow; cognitive; hyperbaric oxygen; perfusion.

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Conflict of interest statement

CONFLICTS OF INTEREST: AH, ES, RBG, SG, BY, ZY work for AVIV Scientific LTD. ES is a shareholder at AVIV Scientific LTD.

Figures

Figure 1
Figure 1
Participants flowchart.
Figure 2
Figure 2
NeuroTrax parameters significant changes. The NeuroTrax significant domains, shown in boxplots, with each line representing a patient flow from baseline to post intervention. The central mark indicates the median, and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. Red symbols indicate outliers.
Figure 3
Figure 3
CANTAB parameters significant changes. The set shifting parameters, shown in boxplots, with each line representing a patient flow from baseline to post intervention. The central mark indicates the median, and the bottom and top edges of the box indicate the 25th and 75th percentiles, respectively. Red symbols indicate outlie.
Figure 4
Figure 4
Brain regions with significant post hyperbaric oxygen therapy changes in cerebral blood flow.
See this image and copyright information in PMC

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