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Comment
. 2020 Jul 7;32(1):1-3.
doi: 10.1016/j.cmet.2020.06.007. Epub 2020 Jun 25.

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Hui Gao  1 , Peter Arner  2 , Gallic Beauchef  3 , Christelle Guéré  3 , Katell Vie  3 , Ingrid Dahlman  2 , Niklas Mejhert  2 , Mikael Rydén  4
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Comment

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Hui Gao et al. Cell Metab. .
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Abstract

Gao et al. report that the observed reduction in adipose lipolysis with age in women could be explained by an upregulation of the catecholamine-degradation pathway in subcutaneous adipocytes. However, in contrast to findings in mice, these pathways are enriched in adipocytes and not in immune cells, suggesting species-specific differences in aging mechanisms.

Keywords: adipocytes; age; body weight; transcriptome.

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Conflict of interest statement

Declaration of Interests The authors declare no competing interests. G.B., C.G., and K.V. are employed by CLARINS Laboratoires.

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