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Review
. 2020 Sep:86:106700.
doi: 10.1016/j.intimp.2020.106700. Epub 2020 Jun 23.

Mechanisms of immune escape in the cancer immune cycle

Sha Tang  1 , Qian Ning  2 , Ling Yang  1 , Zhongcheng Mo  3 , Shengsong Tang  4
Affiliations
Review

Mechanisms of immune escape in the cancer immune cycle

Sha Tang et al. Int Immunopharmacol. 2020 Sep.

Abstract

Cancer is a critical issue globally with high incidence and mortality, imposing great burden on the society. Although great progress has been made in immunotherapy based on immune checkpoint, only a subset of patients responds to this treatment, suggesting that cancer immune evasion is still a major barrier in current immunotherapy. There are a series of factors contributing to immune evasion despite in an immunocompetent environment. Given that these factors are involved in different steps of the cancer immune cycle. In this review, we discuss the mechanisms of immune escape in each step of the cancer immune cycle and then present therapeutic strategies for overcoming immune escape, with the potential to better understand the determinants of immune escape and make anti-tumor immunity more effective.

Keywords: Cancer immune cycle; Immune checkpoint; Immune escape; Immunotherapy.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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