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Case Reports
. 2021 May 1;43(4):e601-e604.
doi: 10.1097/MPH.0000000000001871.

Dysfunctional Immune System Reconstitution After Rituximab Exposure In Utero

Rebecca Clark  1 , Diana Lindsey  2 , Susan Whiteway  1 , Cecilia Mikita  2 , Kenneth Lieuw  3
Affiliations
Case Reports

Dysfunctional Immune System Reconstitution After Rituximab Exposure In Utero

Rebecca Clark et al. J Pediatr Hematol Oncol. .

Abstract

Rituximab is an antibody that binds to B-lymphocytes and is increasingly used during pregnancy. As an immunoglobulin G, it will transfer across the placenta. Previous case reports describe a diversity of clinical presentations in neonates born following rituximab exposure in utero. Our case is the first to offer the long-term experience in the care of an infant with severe neutropenia and prolonged profound hypogammaglobulinemia and class-switching B cell defect after in utero rituximab exposure.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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