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Case Reports
. 2020 Jun 26;99(26):e20861.
doi: 10.1097/MD.0000000000020861.

Primary testicular T-lymphoblastic lymphoma in a child: A case report

Yongren Wang  1   2 , Jian Li  1   2 , Yongjun Fang  1   2
Affiliations
Case Reports

Primary testicular T-lymphoblastic lymphoma in a child: A case report

Yongren Wang et al. Medicine (Baltimore). .

Abstract

Rationale: Primary non-Hodgkin lymphoma (NHL) of the testes is rare, representing about 9% of testicular neoplasms and 1% to 2% of non-Hodgkin lymphomas.

Patient concerns: A previously healthy 47-month-old boy came to our institution for 3 months unilateral testicular swelling without tenderness. After preliminary examination, inguinal orchiectomy was performed to resect the right scrotal mass. The histopathological diagnosis of high-grade lymphoma was rendered and paraffin blocks were sent for immunophenotyping.

Diagnosis: The final diagnosis by histopathological combined with immunohistochemical staining revealed primary testicular T-cell lymphoblastic lymphoma (St Jude Children's Research Hospital Staging System, stage I).

Interventions: The patient was treated with right inguinal orchidectomy followed by chemotherapy (SMCC-2011 protocol modified based on the BFM-90/95 regimen from Germany) without prophylactic radiotherapy to the contralateral testis.

Outcomes: After 36 months of follow-up, the patient is now disease-free without any complication.

Lessons: T-lymphoblastic lymphoma should be considered in the differential diagnosis of testicular masses in children. Intensive chemotherapy may improve the prognosis of such patients.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Mass in the right testis by enhanced abdomen CT scan (A: CT scan, B: CT enhanced scan). CT = computed tomography.
Figure 2
Figure 2
Section from testis shows diffuse neoplastic infiltrate composed of round to oval cells with irregular shaped nuclei and indistinct nucleoli (A, B) (H&E). H&E = hematoxylin and eosin.
Figure 3
Figure 3
Immunophenotype of testis tissue. (C, D, and E) positivity for CD3, TdT, and CD43. F and G, Positive staining for BCL-2 and BCL-6. H, I, and J, Negativity for CD20, CD34, and MPO. K, About 80% of the neoplastic cells display nuclear Ki67 staining.
See this image and copyright information in PMC

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