Do Nicotinic Receptors Modulate High-Order Cognitive Processing?

Abstract

Recent studies provided strong evidence that deficits in cholinergic signaling cause disorders of cognition and affect conscious processing. Technical advances that combine molecular approaches, in vivo recordings in awake behaving animals, human brain imaging, and genetics have strengthened our understanding of the roles of nicotinic acetylcholine receptors (nAChRs) in the modulation of cognitive behavior and network dynamics. Here, we review the emergent role of nAChRs in high-order cognitive processes and discuss recent work implicating cholinergic circuits in cognitive control, including conscious processing.

Keywords: anesthesia; conscious processing; neuropsychiatric disorders; nicotine addiction; nicotinic receptors; prefrontal cortex.