Role of Skeletal Muscle Mitochondrial Dysfunction in CKD

Alice S Ryan^{1

2}

Affiliations

¹ Baltimore Veterans Affairs Medical Center, Division of Gerontology and Geriatric Medicine, Department of Medicine at the University of Maryland School of Medicine, Baltimore, Maryland.
² The Baltimore Geriatric Research, Education and Clinical Center, Veterans Affairs Maryland Health Care System, Baltimore, Maryland.

Editorial

Alice S Ryan. Clin J Am Soc Nephrol. 2020.

. 2020 Jul 1;15(7):912-913.

doi: 10.2215/CJN.08050520. Epub 2020 Jun 26.

Alice S Ryan^{1

2}

¹ Baltimore Veterans Affairs Medical Center, Division of Gerontology and Geriatric Medicine, Department of Medicine at the University of Maryland School of Medicine, Baltimore, Maryland.
² The Baltimore Geriatric Research, Education and Clinical Center, Veterans Affairs Maryland Health Care System, Baltimore, Maryland.

No abstract available

Keywords: Chronic; Muscle; Renal Insufficiency; Skeletal; chronic kidney disease; mitochondria.

Comment on

Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis.
Gamboa JL, Roshanravan B, Towse T, Keller CA, Falck AM, Yu C, Frontera WR, Brown NJ, Ikizler TA. Gamboa JL, et al. Clin J Am Soc Nephrol. 2020 Jul 1;15(7):926-936. doi: 10.2215/CJN.10320819. Epub 2020 Jun 26. Clin J Am Soc Nephrol. 2020. PMID: 32591419 Free PMC article.

1. Wang XH, Mitch WE: Mechanisms of muscle wasting in chronic kidney disease. Nat Rev Nephrol 10: 504–516, 2014 - PMC - PubMed
1. Gamboa JL, Roshanravan B, Towse T, Keller C, Faick A, Yu C, Frontera W, Brown N, Ikizler T: Skeletal muscle mitochondrial dysfunction is present in patients with CKD prior to the initiation of maintenance hemodialysis. Clin J Am Soc Nephrol 15: 926–936, 2020 - PMC - PubMed
1. Gamboa JL, Billings FT 4th, Bojanowski MT, Gilliam LA, Yu C, Roshanravan B, Roberts LJ 2nd, Himmelfarb J, Ikizler TA, Brown NJ: Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. Physiol Rep 4: e12780, 2016 - PMC - PubMed
1. Fazzini F, Lamina C, Fendt L, Schultheiss UT, Kotsis F, Hicks AA, Meiselbach H, Weissensteiner H, Forer L, Krane V, Eckardt KU, Köttgen A, Kronenberg F; GCKD Investigators: Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease. Kidney Int 96: 480–488, 2019 - PubMed
1. Watson EL, Baker LA, Wilkinson TJ, Gould DW, Graham-Brown MPM, Major RW, Ashford RU, Philp A, Smith AC: Reductions in skeletal muscle mitochondrial mass are not restored following exercise training in patients with chronic kidney disease. FASEB J 34: 1755–1767, 2020 - PubMed