Door to the cell for COVID-19 opened, leading way to therapies

doi:10.1038/s41392-020-00215-6

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. 2020 Jun 26;5(1):104.

doi: 10.1038/s41392-020-00215-6.

Door to the cell for COVID-19 opened, leading way to therapies

Zhiwei Huang¹, Jijie Chai²

Affiliations

¹ Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China. huangzhiwei@hit.edu.cn.
² School of Life Sciences, Tsinghua University, Beijing, 100084, China. chaijj@tsinghua.edu.cn.

PMID: 32591496
PMCID: PMC7317891
DOI: 10.1038/s41392-020-00215-6

Comment

Door to the cell for COVID-19 opened, leading way to therapies

Zhiwei Huang et al. Signal Transduct Target Ther. 2020.

. 2020 Jun 26;5(1):104.

doi: 10.1038/s41392-020-00215-6.

Authors

Zhiwei Huang¹, Jijie Chai²

Affiliations

¹ Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China. huangzhiwei@hit.edu.cn.
² School of Life Sciences, Tsinghua University, Beijing, 100084, China. chaijj@tsinghua.edu.cn.

PMID: 32591496
PMCID: PMC7317891
DOI: 10.1038/s41392-020-00215-6

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1**
Structural superposition of SARS-CoV-2 and SARS-CoV RBMs binding to ACE2 receptor. Structural alignment of the SARS-CoV-2 RBD/ACE2 (cyan) and SARS-CoV RBD/ACE2 (pink) complexes (left). The RBM of SARS-CoV-2 and SARS-CoV is shown in yellow and purple, respectively. The remaining portion of the two RBDs is shown in gray. The PDB codes for SARS-CoV-2 RBM/ACE2 and SARS-CoV RBM/ACE2 are 6M0J and 2AJF, respectively. The interface of SARS-CoV-2 RBD and ACE2 receptor is shown in surface view (right). RBD and ACE2 are colored in yellow and cyan, respectively

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Comment on

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.
Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L, Wang X. Lan J, et al. Nature. 2020 May;581(7807):215-220. doi: 10.1038/s41586-020-2180-5. Epub 2020 Mar 30. Nature. 2020. PMID: 32225176

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References

1. Lan, J. et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature10.1038/s41586-020-2180-5 (2020). - PubMed
1. Li F. Structure, function, and evolution of coronavirus spike proteins. Annu. Rev. Virol. 2016;3:237–261. doi: 10.1146/annurev-virology-110615-042301. - DOI - PMC - PubMed
1. Li W, et al. Angiotensin-converting enzyme 2 is afunctional receptor for the SARS coronavirus. Nature. 2003;426:450–454. doi: 10.1038/nature02145. - DOI - PMC - PubMed
1. Wrapp D, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367:1260–1263. doi: 10.1126/science.abb2507. - DOI - PMC - PubMed
1. Tian X, et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg. Microbes Infect. 2020;9:382–385. doi: 10.1080/22221751.2020.1729069. - DOI - PMC - PubMed

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[1] Lan, J. et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature10.1038/s41586-020-2180-5 (2020). - PubMed

[2] Lan, J. et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature10.1038/s41586-020-2180-5 (2020). - PubMed

[3] Li F. Structure, function, and evolution of coronavirus spike proteins. Annu. Rev. Virol. 2016;3:237–261. doi: 10.1146/annurev-virology-110615-042301. - DOI - PMC - PubMed

[4] Li F. Structure, function, and evolution of coronavirus spike proteins. Annu. Rev. Virol. 2016;3:237–261. doi: 10.1146/annurev-virology-110615-042301. - DOI - PMC - PubMed

[5] Li W, et al. Angiotensin-converting enzyme 2 is afunctional receptor for the SARS coronavirus. Nature. 2003;426:450–454. doi: 10.1038/nature02145. - DOI - PMC - PubMed

[6] Li W, et al. Angiotensin-converting enzyme 2 is afunctional receptor for the SARS coronavirus. Nature. 2003;426:450–454. doi: 10.1038/nature02145. - DOI - PMC - PubMed

[7] Wrapp D, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367:1260–1263. doi: 10.1126/science.abb2507. - DOI - PMC - PubMed

[8] Wrapp D, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367:1260–1263. doi: 10.1126/science.abb2507. - DOI - PMC - PubMed

[9] Tian X, et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg. Microbes Infect. 2020;9:382–385. doi: 10.1080/22221751.2020.1729069. - DOI - PMC - PubMed

[10] Tian X, et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg. Microbes Infect. 2020;9:382–385. doi: 10.1080/22221751.2020.1729069. - DOI - PMC - PubMed

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Door to the cell for COVID-19 opened, leading way to therapies

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Door to the cell for COVID-19 opened, leading way to therapies

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