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Review
. 2020 Sep 1;75(9):2381-2383.
doi: 10.1093/jac/dkaa272.

The challenging pathway towards the identification of SARS-CoV-2/COVID-19 therapeutics

Marco Siccardi  1 , Jonathan Schapiro  2 , Giovanni Di Perri  3 , David J Back  1
Affiliations
Review

The challenging pathway towards the identification of SARS-CoV-2/COVID-19 therapeutics

Marco Siccardi et al. J Antimicrob Chemother. .

Abstract

The development of therapeutic agents against SARS-CoV-2/COVID-19 faces numerous barriers and a multidisciplinary approach to evaluating drug efficacy and toxicity is essential. Experimental and preclinical data should be integrated into a comprehensive analysis, where drug potency, the timing of therapy initiation, drug combinations, variability in systemic and local drug exposure and short- and long-term toxicities represent fundamental factors for the rational identification of candidates and prioritization of clinical investigations. Although the identification of SARS-CoV-2 therapeutics is a priority, rigorous and transparent methodologies are crucial to ensure that accelerated research programmes result in high-quality and reproducible findings.

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