Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan;93(1):441-447.
doi: 10.1002/jmv.26230. Epub 2020 Aug 21.

Analysis of the diagnostic value of serum specific antibody testing for coronavirus disease 2019

Meitian Yan  1   2 , Yutong Zheng  1   2 , Yanmei Sun  3 , Lan Wang  2 , Liang Luan  2 , Jing Liu  2 , Xiao Tian  2 , Nan Wan  2
Affiliations

Analysis of the diagnostic value of serum specific antibody testing for coronavirus disease 2019

Meitian Yan et al. J Med Virol. 2021 Jan.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has spread to various regions worldwide. As of 27 April 2020, according to real-time statistics released by the World Health Organization, there have been 84 341 confirmed cases and 4643 deaths in China, with more than 2 979 484 confirmed cases and 206 450 deaths outside China. The detection of antibodies produced during the immune response to severe acute respiratory syndrome coronavirus 2 infections has become an important laboratory method for the diagnosis of COVID-19. However, at present, a little research on these specific antibodies has been conducted. In this study, a retrospective analysis was used to explore the dynamic changes of serum immunoglobulin M (IgM) and IgG antibody and factors affecting diagnostic efficacy, so as to provide a theoretical basis for clinical diagnosis and treatment.

Keywords: COVID-19; IgG; IgM; SARS-CoV-2.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Dynamic changes in the positive rates in patients after the onset of disease. A, Heat map of changes in the positive rates of antibodies. B, Changes in the positive rates of nucleic acid and antibodies at different time periods after coronavirus disease 2019 onset. IgM, immunoglobulin M
Figure 2
Figure 2
Dynamic changes of antibody levels in patients after the disease onset. IgM, immunoglobulin M
Figure 3
Figure 3
The influence of sex, comorbidity status, symptoms, and the severity of illness on immunoglobulin G (IgG) antibody levels. Comparison of IgG antibody levels and (A) sex, (B) comorbidity and noncomorbidity groups, (C) symptomatic and asymptomatic groups, and (D) nonsevere and severe groups
Figure 4
Figure 4
Correlation analysis of immunoglobulin G (IgG) antibody levels with (A) age, (B) albumin (ALB) levels, and (C) total protein (TP) levels
See this image and copyright information in PMC

References

    1. Gorbalenya AE, Baker SC, Baric RS, et al. Severe acute respiratory syndrome‐related coronavirus: the species and its viruses—a statement of the coronavirus study group. bioRxiv. 2020.
    1. Guan W, Ni Z, Hu Y, et al. Clinical characteristics of 2019 novel coronavirus infection in China. medRxiv. 2020.
    1. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727‐733. - PMC - PubMed
    1. Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS‐CoV‐2. Nat Med. 2020;26(4):450‐452. - PMC - PubMed
    1. Ortega VE, Li X, O'neal WK, et al. Development and clinical application of a rapid IgM‐IgG combined antibody test for SARS‐CoV‐2 infection diagnosis. J Med Virol. 2020;201:540‐554. - PMC - PubMed

Publication types