Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep;60(8):1592-1600.
doi: 10.1111/head.13888. Epub 2020 Jun 27.

Cranial Autonomic Symptoms of Migraine in Japan: Prospective Study of 373 Migraine Patients at a Tertiary Headache Center

Daisuke Danno  1 , Johanna Wolf  2 , Kumiko Ishizaki  1 , Shoji Kikui  1 , Hiroo Yoshikawa  3 , Takao Takeshima  1
Affiliations

Cranial Autonomic Symptoms of Migraine in Japan: Prospective Study of 373 Migraine Patients at a Tertiary Headache Center

Daisuke Danno et al. Headache. 2020 Sep.

Abstract

Objective: To clarify the detailed clinical characteristics of cranial autonomic symptoms (CAS) of Japanese patients with migraine and to get insight into the pathophysiological implications.

Background: Recent studies reported that CAS in migraine is causing diagnostic confusion with cluster headache or sinus headache; however, most reports have concerned Caucasians, and Asian data are scarce. The regional differences in the clinical characteristics of primary headaches between Caucasians and Asians have also been revealed recently.

Method: This was a cross-sectional study. We investigated 373 patients with migraine in a tertiary headache center with face-to-face interviews.

Results: According to our findings, 158/373 (42.4%) patients with migraine had CAS and were characterized by more frequent cutaneous allodynia than those without CAS, suggesting the contribution of central sensitization; however, there were no statistically significant differences in pulsating pain or motion sensitivity as signs of peripheral sensitization. In contrast to the previous study, osmophobia was found to be significantly related to CAS.

Conclusion: CAS in patients with migraine is common not only in Caucasians but also in Asians. Central sensitization seems to contribute more than peripheral sensitization to CAS manifestation, and osmophobia might be noteworthy among Asian patients with migraine. To avoid a misdiagnosis, we emphasize the need for comments on CAS in the international classification of headache disorders migraine criteria.

Keywords: Asia; central sensitization; cranial autonomic symptoms; cutaneous allodynia; migraine; osmophobia.

PubMed Disclaimer

References

    1. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1-211.
    1. Goadsby PJ, Lipton RB. A review of paroxysmal hemicranias, SUNCT syndrome and other short-lasting headaches with autonomic feature, including new cases. Brain. 1997;120:193-209.
    1. Blau JN, Davis E. Small blood-vessels in migraine. Lancet. 1970;740-742.
    1. Obermann M, Yoon MS, Dommes P, et al. Prevalence of trigeminal autonomic symptoms in migraine: A population-based study. Cephalalgia. 2007;27:504-509.
    1. Barbanti P, Aurilia C, Dall'Armi V, et al. The phenotype of migraine with unilateral cranial autonomic symptoms documents increased peripheral and central trigeminal sensitization. A case series of 757 patients. Cephalalgia. 2016;36:1334-1340.

LinkOut - more resources