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Editorial
. 2020 Dec;75(12):1583-1586.
doi: 10.1111/anae.15186. Epub 2020 Jun 27.

Measuring the effect-site

M G Irwin  1 , C K E Chung  1 , G T C Wong  1
Affiliations
Free article
Editorial

Measuring the effect-site

M G Irwin et al. Anaesthesia. 2020 Dec.
Free article
No abstract available

Keywords: effect-site; intravenous anaesthesia; pharmacodynamics; pharmacokinetics; propofol: administration; remifentanil.

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References

    1. Van Hese L, Theys T, Absalom AR, Rex S, Cuypers E. Comparison of predicted and real propofol and remifentanil concentrations in plasma and brain tissue during target-controlled infusion: a prospective observational study. Anaesthesia 2020; 75: 1626-34.
    1. Cortínez LI. What is the ke0 and what does it tell me about propofol? Anaesthesia 2014; 69: 399-402.
    1. Ludbrook GL, Visco E, Lam AM. Propofol: relation between brain concentrations, electroencephalogram, middle cerebral artery blood flow velocity, and cerebral oxygen extraction during induction of anesthesia. Anesthesiology 2002; 97: 1363-70.
    1. Bjornsson MA, Norberg A, Kalman S, Karlsson MO, Simonsson US. A two-compartment effect site model describes the bispectral index after different rates of propofol infusion. Journal of Pharmacokinetics and Pharmacodynamics 2010; 37: 243-55.
    1. Sahinovic MM, Eleveld DJ, Miyabe-Nishiwaki T, Struys M, Absalom AR. Pharmacokinetics and pharmacodynamics of propofol: changes in patients with frontal brain tumours. British Journal of Anaesthesia 2017; 118: 901-9.

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