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Review
. 2018 Jun 7;52(2):71-78.
doi: 10.14744/SEMB.2017.51422. eCollection 2018.

Neonatal Diabetes Mellitus

Adil Umut Zübarioğlu  1 , Ali Bülbül  1 , Hasan Sinan Uslu  1
Affiliations
Review

Neonatal Diabetes Mellitus

Adil Umut Zübarioğlu et al. Sisli Etfal Hastan Tip Bul. .

Abstract

Neonatal diabetes is a rare cause of hyperglycemia in the neonatal period. It is caused by mutations in genes that encode proteins playing critical roles in normal functions of pancreatic beta cells. Neonatal diabetes is divided into temporary and permanent subtypes. Treatment is based on the correction of fluid-electrolyte disturbances and hyperglycemia. Patients respond to insulin or sulfonylurea treatment according to the mutation type. Close glucose monitoring and education of caregivers about diabetes are vital.

Keywords: Insulin therapy; neonatal diabetes mellitus; sulfonylurea.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Rubio-Cabezas O, Ellard S. Diabetes mellitus in neonates and infants: genetic heterogeneity, clinical approach to diagnosis, and therapeutic options. Horm Res Paediatr. 2013;80:137–46. - PMC - PubMed
    1. Støy J, Steiner DF, Park SY, Ye H, Philipson LH, Bell GI. Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene. Rev Endocr Metab Disord. 2010;11:205–15. - PMC - PubMed
    1. De Franco E, Flanagan SE, Houghton JA, Lango Allen H, Mackay DJ, Temple IK, et al. The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study. Lancet. 2015;386:957–63a. - PMC - PubMed
    1. von Mühlendahl KE, Herkenhoff H. Long-term course of neonatal diabetes. N Engl J Med. 1995;333:704–8. - PubMed
    1. Murphy R, Ellard S, Hattersley AT. Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab. 2008;4:200–13. - PubMed

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