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. 2020 Jun 10:2020:8303716.
doi: 10.1155/2020/8303716. eCollection 2020.

Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study

Jisook Yoo  1 , Ji Young Choi  1 , Bo Young Lee  1 , Chang Ho Shin  2 , Jung-Won Shin  1 , Chang Hun Huh  1 , Jung-Im Na  1
Affiliations

Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study

Jisook Yoo et al. Evid Based Complement Alternat Med. .

Abstract

Background: Saline groundwater, collected from the east coast of Korea, has been shown to have protective effects against 2,4-dinitrochlorobenzene- (DNCB-) induced atopic dermatitis-like skin lesions in the murine model.

Objectives: To determine the effects of saline groundwater solution baths as a treatment of mild-to-moderate atopic dermatitis.

Methods: Twenty-four subjects with mild-to-moderate atopic dermatitis were instructed to take a bath in saline groundwater solution for 20 minutes per day for two weeks. Evaluations were performed at baseline and week 2, including SCORing Atopic Dermatitis (SCORAD) index, corneometry, transepidermal water loss, visual analogue scale for pruritus, and collection of adverse events.

Results: Subjects showed significant improvement with respect to the SCORAD index, skin hydration, transepidermal water loss, and pruritus at week 2 when compared with the baseline.

Conclusion: Baths in saline groundwater solution may be an alternative therapeutic strategy for treating atopic dermatitis.

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Conflict of interest statement

However, the company did not have any role in the study design, data collection and analysis, the decision to publish, or the preparation of this manuscript.

Figures

Figure 1
Figure 1
Fifty-fold concentrated SGW in 1 L bottles and a 20 L-sized bucket provided to the participants for dilution.
Figure 2
Figure 2
The mean SCORAD index score, corneometry, TEWL, and VAS for pruritus of atopic dermatitis patients treated with SGW bath. (a) SCORAD index score decreased after SGW bath treatment. The average SCORAD index score decreased from 36.6 ± 10.80 to 20.73 ± 12.41 at week 2. (b) Skin hydration increased from 24.72 ± 16.47 to 42.67 ± 7.66. (c) TEWL was reduced from 18.80 ± 8.21 to 11.35 ± 4.33 after treatment. (d) Pruritus improved after treatment. ∗∗∗P < 0.005 (SCORAD, SCORing of Atopic Dermatitis; TEWL, transepidermal water loss; SGW, saline groundwater).
See this image and copyright information in PMC

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