Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jun 24:9:F1000 Faculty Rev-639.
doi: 10.12688/f1000research.22237.1. eCollection 2020.

Recent advances in understanding glucose transport and glucose disposal

Ann Louise Olson  1 , Kenneth Humphries  1   2
Affiliations
Review

Recent advances in understanding glucose transport and glucose disposal

Ann Louise Olson et al. F1000Res. .

Abstract

Deficient glucose transport and glucose disposal are key pathologies leading to impaired glucose tolerance and risk of type 2 diabetes. The cloning and identification of the family of facilitative glucose transporters have helped to identify that underlying mechanisms behind impaired glucose disposal, particularly in muscle and adipose tissue. There is much more than just transporter protein concentration that is needed to regulate whole body glucose uptake and disposal. The purpose of this review is to discuss recent findings in whole body glucose disposal. We hypothesize that impaired glucose uptake and disposal is a consequence of mismatched energy input and energy output. Decreasing the former while increasing the latter is key to normalizing glucose homeostasis.

Keywords: glucose disposal; glucose transport; insulin resistance.

PubMed Disclaimer

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

References

    1. Klip A, McGraw TE, James DE: Thirty sweet years of GLUT4. J Biol Chem. 2019;294(30):11369–81. 10.1074/jbc.REV119.008351 - DOI - PMC - PubMed

    2. Faculty Opinions Recommendation

    1. Boersma GJ, Johansson E, Pereira MJ, et al. : Altered Glucose Uptake in Muscle, Visceral Adipose Tissue, and Brain Predict Whole-Body Insulin Resistance and may Contribute to the Development of Type 2 Diabetes: A Combined PET/MR Study. Horm Metab Res. 2018;50(8):627–39. 10.1055/a-0643-4739 - DOI - PubMed

    2. Faculty Opinions Recommendation

    1. Roberts-Thomson KM, Betik AC, Premilovac D, et al. : Postprandial microvascular blood flow in skeletal muscle: Similarities and disparities to the hyperinsulinaemic-euglycaemic clamp. Clin Exp Pharmacol Physiol. 2020;47(4):725–37. 10.1111/1440-1681.13237 - DOI - PubMed

    2. Faculty Opinions Recommendation

    1. McConell GK, Sjøberg KA, Ceutz F, et al. : Insulin-induced membrane permeability to glucose in human muscles at rest and following exercise. J Physiol. 2020;598(2):303–15. 10.1113/JP278600 - DOI - PubMed

    2. Faculty Opinions Recommendation

    1. Henstridge DC, Kingwell BA, Formosa MF, et al. : Effects of the nitric oxide donor, sodium nitroprusside, on resting leg glucose uptake in patients with type 2 diabetes. Diabetologia. 2005;48(12):2602–8. 10.1007/s00125-005-0018-1 - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources