SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis

doi:10.3389/fcimb.2020.00340

. 2020 Jun 12:10:340.

doi: 10.3389/fcimb.2020.00340. eCollection 2020.

SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis

M Victoria Delpino^{1

2}, Jorge Quarleri^{2

3}

Affiliations

¹ Facultad de Farmacia y Bioquímica, Instituto de Inmunología, Genética y Metabolismo (INIGEM), Universidad de Buenos Aires, Buenos Aires, Argentina.
² Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
³ Facultad de Medicina, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.

PMID: 32596170
PMCID: PMC7303284
DOI: 10.3389/fcimb.2020.00340

SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis

M Victoria Delpino et al. Front Cell Infect Microbiol. 2020.

. 2020 Jun 12:10:340.

doi: 10.3389/fcimb.2020.00340. eCollection 2020.

Authors

M Victoria Delpino^{1

2}, Jorge Quarleri^{2

3}

Affiliations

¹ Facultad de Farmacia y Bioquímica, Instituto de Inmunología, Genética y Metabolismo (INIGEM), Universidad de Buenos Aires, Buenos Aires, Argentina.
² Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
³ Facultad de Medicina, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.

PMID: 32596170
PMCID: PMC7303284
DOI: 10.3389/fcimb.2020.00340

No abstract available

Keywords: ACE2; ANG1-7; Fibrosis; Renin angiotensin system (RAS); SARS-CoV-2.

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Figures

**Figure 1**
The renin–angiotensin system in homeostasis and in SARS-Cov-2 infection. Angiotensin I (AgnI), Angiotensin II (AgnII), Angiotensin 1-7 (Agn1-7), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2).

See this image and copyright information in PMC

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References

1. Chen G., Wu D., Guo W., Cao Y., Huang D., Wang H., et al. . (2020). Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J. Clin. Invest. 130, 2620–2629. 10.1172/JCI137244 - DOI - PMC - PubMed
1. Cofre C., Acuna M. J., Contreras O., Morales M. G., Riquelme C., Cabello-Verrugio C., et al. (2015). Transforming growth factor type-beta inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; relevance to fibrosis associated to muscular dystrophies. Biofactors 41, 111–120. 10.1002/biof.1208 - DOI - PubMed
1. da Silveira K. D., Coelho F. M., Vieira A. T., Sachs D., Barroso L. C., Costa V. V., et al. . (2010). Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, MAS, in experimental models of arthritis. J. Immunol. 185, 5569–5576. 10.4049/jimmunol.1000314 - DOI - PubMed
1. Gao X., He X., Luo B., Peng L., Lin J., Zuo Z. (2009). Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts. Eur. J. Pharmacol. 606, 115–120. 10.1016/j.ejphar.2008.12.049 - DOI - PubMed
1. Gava E., Samad-Zadeh A., Zimpelmann J., Bahramifarid N., Kitten G. T., Santos R. A., et al. . (2009). Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells. Nephrol. Dial. Transplant. 24, 1766–1773. 10.1093/ndt/gfn736 - DOI - PMC - PubMed

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[1] Chen G., Wu D., Guo W., Cao Y., Huang D., Wang H., et al. . (2020). Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J. Clin. Invest. 130, 2620–2629. 10.1172/JCI137244 - DOI - PMC - PubMed

[2] Chen G., Wu D., Guo W., Cao Y., Huang D., Wang H., et al. . (2020). Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J. Clin. Invest. 130, 2620–2629. 10.1172/JCI137244 - DOI - PMC - PubMed

[3] Cofre C., Acuna M. J., Contreras O., Morales M. G., Riquelme C., Cabello-Verrugio C., et al. (2015). Transforming growth factor type-beta inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; relevance to fibrosis associated to muscular dystrophies. Biofactors 41, 111–120. 10.1002/biof.1208 - DOI - PubMed

[4] Cofre C., Acuna M. J., Contreras O., Morales M. G., Riquelme C., Cabello-Verrugio C., et al. (2015). Transforming growth factor type-beta inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; relevance to fibrosis associated to muscular dystrophies. Biofactors 41, 111–120. 10.1002/biof.1208 - DOI - PubMed

[5] da Silveira K. D., Coelho F. M., Vieira A. T., Sachs D., Barroso L. C., Costa V. V., et al. . (2010). Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, MAS, in experimental models of arthritis. J. Immunol. 185, 5569–5576. 10.4049/jimmunol.1000314 - DOI - PubMed

[6] da Silveira K. D., Coelho F. M., Vieira A. T., Sachs D., Barroso L. C., Costa V. V., et al. . (2010). Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, MAS, in experimental models of arthritis. J. Immunol. 185, 5569–5576. 10.4049/jimmunol.1000314 - DOI - PubMed

[7] Gao X., He X., Luo B., Peng L., Lin J., Zuo Z. (2009). Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts. Eur. J. Pharmacol. 606, 115–120. 10.1016/j.ejphar.2008.12.049 - DOI - PubMed

[8] Gao X., He X., Luo B., Peng L., Lin J., Zuo Z. (2009). Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts. Eur. J. Pharmacol. 606, 115–120. 10.1016/j.ejphar.2008.12.049 - DOI - PubMed

[9] Gava E., Samad-Zadeh A., Zimpelmann J., Bahramifarid N., Kitten G. T., Santos R. A., et al. . (2009). Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells. Nephrol. Dial. Transplant. 24, 1766–1773. 10.1093/ndt/gfn736 - DOI - PMC - PubMed

[10] Gava E., Samad-Zadeh A., Zimpelmann J., Bahramifarid N., Kitten G. T., Santos R. A., et al. . (2009). Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells. Nephrol. Dial. Transplant. 24, 1766–1773. 10.1093/ndt/gfn736 - DOI - PMC - PubMed

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SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis

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SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis

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