Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May;32(110):147-153.
doi: 10.22038/ijorl.2020.43213.2418.

Effects of Rheumatoid Arthritis on the Larynx

Mehdi Dehghan  1 , Akram Ahmadi  1 , Behnaz Yousefghahari  2 , Keyvan Kiakojouri  2 , Hemmat Gholinia  2
Affiliations

Effects of Rheumatoid Arthritis on the Larynx

Mehdi Dehghan et al. Iran J Otorhinolaryngol. 2020 May.

Abstract

Introduction: The aim of the present study was to compare the videolaryngostroboscopic findings between patients with rheumatoid arthritis and vocally healthy controls.

Materials and methods: This case-control descriptive study was performed on 113 people, including 50 patients with rheumatoid arthritis and 63 controls. The participants were subjected to videolaryngostroboscopic examinations in order to evaluate fundamental frequency, different structural vocal lesions, patterns of glottal closure, subglottal changes, supraglottis appearance, and movement patterns of the arytenoid cartilage. The obtained results were compared between the two research groups. Data analysis was performed in the Statistical Package for the Social Sciences, version 24.0. A p-value less than 0.05 was considered statistically significant.

Results: The results revealed a statistically significant difference between the two groups in terms of the complete pattern (P=0.00) and strained state of glottal closure (P=0.00), pattern of subglottal changes (χ2=25.98, df=2; P<0.001), and movement patterns of the arytenoid (χ2=21.16, df=1; P<0.001). Additionally, based on the obtained frequencies, the two groups showed significant differences regarding the normal state of the larynx (P=0.00), hypertrophy of vocal fold (P=0.007), epithelial change (P=0.007), and Reinke's edema (P=0.001). However, the videolaryngostroboscopic examination results revealed no significant difference between the two groups in terms of polyp (P=0.20), nodule (P=0.57), sulcus vocalis (P=0.08), cyst (P=0.45), and atrophy of vocal folds (P=0.45).

Conclusion: It seems that rheumatoid arthritis affects the patterns of arytenoids movement, some kinds of glottal closure patterns, and subglottal changes. As the results indicated, the occurrence of some laryngeal structural changes was higher in patients with rheumatoid arthritis than in individuals without this disorder.

Keywords: Larynx; Rheumatoid arthritis; Vocal cords; Voice.

PubMed Disclaimer

References

    1. Geterud A. Rheumatoid arthritis in the larynx: A clinical and methodological study. 1993.
    1. Kosztyła-Hojna B, Moskal D, Kuryliszyn-Moskal A. Parameters of the assessment of voice quality and clinical manifestation of rheumatoid arthritis. Advances in medical sciences. 2015;60(2):321–8. - PubMed
    1. Speyer R, Speyer I, Heijnen MA. Prevalence and relative risk of dysphonia in rheumatoid arthritis. Journal of Voice. 2008;22(2):232–7. - PubMed
    1. Fisher BA, Dolan K, Hastings L, McClinton C, Taylor PC. Prevalence of subjective voice impairment in rheumatoid arthritis. Clinical rheumatology. 2008;27(11) - PubMed
    1. Roy N, Tanner K, Merrill RM, Wright C, Miller KL, Kendall KA. Descriptive epidemiology of voice disorders in rheumatoid arthritis: prevalence, risk factors, and quality of life burden. Journal of Voice. 2016;30(1):74–87. - PubMed

LinkOut - more resources