Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jun 12:8:483.
doi: 10.3389/fbioe.2020.00483. eCollection 2020.

Recent Development of Extremophilic Bacteria and Their Application in Biorefinery

Daochen Zhu  1   2 , Wasiu Adewale Adebisi  1 , Fiaz Ahmad  1 , Sivasamy Sethupathy  1 , Blessing Danso  1 , Jianzhong Sun  1
Affiliations
Review

Recent Development of Extremophilic Bacteria and Their Application in Biorefinery

Daochen Zhu et al. Front Bioeng Biotechnol. .

Abstract

The biorefining technology for biofuels and chemicals from lignocellulosic biomass has made great progress in the world. However, mobilization of laboratory research toward industrial setup needs to meet a series of criteria, including the selection of appropriate pretreatment technology, breakthrough in enzyme screening, pathway optimization, and production technology, etc. Extremophiles play an important role in biorefinery by providing novel metabolic pathways and catalytically stable/robust enzymes that are able to act as biocatalysts under harsh industrial conditions on their own. This review summarizes the potential application of thermophilic, psychrophilic alkaliphilic, acidophilic, and halophilic bacteria and extremozymes in the pretreatment, saccharification, fermentation, and lignin valorization process. Besides, the latest studies on the engineering bacteria of extremophiles using metabolic engineering and synthetic biology technologies for high-efficiency biofuel production are also introduced. Furthermore, this review explores the comprehensive application potential of extremophiles and extremozymes in biorefinery, which is partly due to their specificity and efficiency, and points out the necessity of accelerating the commercialization of extremozymes.

Keywords: biofuel; biorefinery; extremophiles; extremozymes; synthetic biology.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A simple flow line sketch of extremozymes production and application.
Figure 2
Figure 2
Application of extremozymes in bioenergy and biochemicals production.
Figure 3
Figure 3
Extremophilic adaptation mechanisms of extremophiles in response to environmental stress.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abe F., Horikoshi K. (2000). Tryptophan permease gene TAT2 confers high-pressure growth in Saccharomyces cerevisiae. Mol. Cell. Biol. 20, 8093–8102. 10.1128/MCB.20.21.8093-8102.2000 - DOI - PMC - PubMed
    1. Ábrego U., Chen Z., Wan C. (2017). Chapter Three - consolidated bioprocessing systems for cellulosic biofuel production, in Advances in Bioenergy, eds Li Y., Ge X. (Amsterdam: Elsevier; ), 143–182. 10.1016/bs.aibe.2017.01.002 - DOI
    1. Acevedo-Rocha C. G., Hoesl M. G., Nehring S., Royter M., Wolschner C., Wiltschi B., et al. (2013). Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments. Catalysis Sci. Technol. 3, 1198–1201. 10.1039/c3cy20712a - DOI
    1. Adams R. L., Terry L. J., Wente S. R. (2016). A novel Saccharomyces cerevisiae FG nucleoporin mutant collection for use in nuclear pore complex functional experiments. G3: Genes, Genomes, Genet. 6, 51–58. 10.1534/g3.115.023002 - DOI - PMC - PubMed
    1. Adesioye F. A., Makhalanyane T. P., Vikram S., Sewell B. T., Schubert W. D., Cowan D. A. (2018). Structural characterization and directed evolution of a novel acetyl xylan esterase reveals thermostability determinants of the carbohydrate esterase 7 family. Appl. Environ. Microbiol. 84, e02695–e02617. 10.1128/AEM.02695-17 - DOI - PMC - PubMed

LinkOut - more resources